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Record W4400619310 · doi:10.1101/2024.07.09.602765

Structural variants underlie parallel adaptation following global invasion

2024· preprint· en· W4400619310 on OpenAlexaff
Paul Battlay, Brandon T Hendrickson, Jonas I Mendez-Reneau, James S. Santangelo, Lucas J. Albano, Jonathan P. Wilson, Aude E. Caizergues, Nevada King, Adriana Puentes, Amelia Tudoran, Cyrille Violle, François Vasseur, Courtney M. Patterson, Michael Foster, Caitlyn Stamps, Simon G. Innes, Rémi Allio, Fábio Angeoletto, Daniel N. Anstett, Julia Anstett, Anna Bucharová, Mattheau S. Comerford, Santiago David, Mohsen Falahati‐Anbaran, William Godsoe, César González‐Lagos, Pedro E. Gundel, Glen R. Hood, Regina Karousou, Christian Lampei, Carlos Lara, Adrián Lázaro‐Lobo, Deleon da Silva Leandro, Thomas Merritt, Nora Mitchell, Mitra Mohammadi Bazargani, Angela T. Moles, Maureen Murúa, Juraj Paule, Vera Pfeiffer, Joost A. M. Raeymaekers, Diana J. Rennison, Rodrigo S. Ríos, Jennifer K. Rowntree, Adam C. Schneider, Kaitlin Stack Whitney, Ítalo Tamburrino, Acer VanWallendael, Paul Kim, Rob W. Ness, Marc T. J. Johnson, Kathryn A. Hodgins, Nicholas J. Kooyers

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2024
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic diversity and population structure
Canadian institutionsUniversity of British ColumbiaLaurentian UniversityUniversity of Toronto
Fundersnot available
KeywordsAdaptation (eye)BiologyLocal adaptationParallel evolutionEvolutionary biologyColonizationGenetic variationStructural variationSelection (genetic algorithm)Range (aeronautics)GenomeGeneticsEcologyGenePhylogeneticsPopulation

Abstract

fetched live from OpenAlex

Rapid adaptation during invasion has historically been considered limited and unpredictable. We leverage whole-genome sequencing of >2600 plants across six continents to investigate the relative roles of colonization history and adaptation during the worldwide invasion of Trifolium repens. Introduced populations contain high levels of genetic variation with independent colonization histories evident on different continents. Five large structural variants on three chromosomes exist as standing genetic variation within the native range, and exhibit strong signatures of parallel climate-associated adaptation across continents. Common gardens in the native and introduced ranges demonstrate that three structural variants exhibit patterns of selection consistent with local adaptation across each range. Our results provide strong evidence that rapid and parallel adaptation during invasion is caused by large-effect structural variants introduced throughout the world.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.234
Teacher spread0.213 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2024
Admission routes1
Has abstractyes

Explore more

Same venuebioRxiv (Cold Spring Harbor Laboratory)→Same topicGenetic diversity and population structure→French-language works237,207→