Takotsubo Cardiomyopathy After Oxaliplatin Chemotherapy Exposure: A Case Report
Bibliographic record
Abstract
Oxaliplatin is a platinum-based chemotherapeutic agent employed in conjunction with either fluorouracil or capecitabine in treatment of advanced colorectal cancer.Takotsubo cardiomyopathy (TCM) represents a stressinduced ventricular dysfunction with regional wall-motion abnormalities not tied to a single coronary territory.Although fluorouracil and capecitabine have more well-documented associations with TCM, oxaliplatin's association is far rarer.We describe a patient with cecal adenocarcinoma who developed new-onset heart failure secondary to TCM, following oxaliplatin administration.This case is only the third such documented, and the first with a baseline echocardiogram for comparison.However, the incidence of oxaliplatin-induced TCM may be underrecognized in the literature. CaseA 69-year-old female patient who underwent right colectomy with resection of surrounding structures (appendix, fallopian tube, ovary, bladder dome) 4 months prior, for cecal adenocarcinoma, was initiated on oxaliplatin chemotherapy as part of a capecitabineeoxaliplatin (CAPOX) regimen, alongside capecitabine.At the time of oxaliplatin initiation, she had not received any doses of capecitabine.Her past medical history was notable for hypertension, dyslipidemia, asthma, celiac disease, and osteoporosis.She also had been an active cigarette smoker for > 45 years at the time of her presentation, and she had been taking only atorvastatin, 40 mg once daily, and inhaling fluticasoneesalmeterol twice daily as needed.Twenty minutes prior to her first oxaliplatin infusion, she received single doses of oral dexamethasone, 12 mg, and oral ondansetron, 8 mg.She denied experiencing any recent significant emotional or physical stressors or use of over-the-
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.004 |
| Meta-epidemiology (narrow) | 0.003 | 0.002 |
| Meta-epidemiology (broad) | 0.002 | 0.003 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.005 | 0.003 |
| Scholarly communication | 0.003 | 0.004 |
| Open science | 0.002 | 0.003 |
| Research integrity | 0.009 | 0.005 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".