Dynamic Insights into Dopamine Axon Growth in Adolescence and its Implications for Psychiatric Risk
Bibliographic record
Abstract
Adolescence and the development of the dopaminergic system have long been shown to be inextricably linked. Common adolescent experiences, such as substance exposure and stress, can alter dopamine axon growth and influence behavior in adulthood. Additionally, the Netrin-1/DCC (Deleted in Colorectal Cancer) guidance cue system is implicated in regulating dopamine axon growth during adolescence. Here, we summarize the literature into the pivotal role of adolescence in animal development, with a specific focus on the maturation process of the mesocorticolimbic dopamine system. We outline the diverse structure of this system, recent findings on axonal targeting and pathfinding processes during adolescence, as well as the implications of this research for psychiatric pathology. We argue that the current body of research suggests a link between delayed dopamine axon growth and adolescent neuroplasticity, providing insights into the incidence of psychiatric disorders during this critical developmental period.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".