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Record W4401175072 · doi:10.1016/j.gim.2024.101226

Discovery of DNA methylation signature in the peripheral blood of individuals with history of antenatal exposure to valproic acid

2024· article· en· W4401175072 on OpenAlexafffund
Sadegheh Haghshenas, Audrey Putoux, Jack Reilly, Michael A. Levy, Raissa Relator, Sourav Ghosh, Jennifer Kerkhof, Haley McConkey, Patrick Edery, Gaëtan Lesca, Alicia Besson, Christine Coubes, Marjolaine Willems, Nathalie Ruiz-Pallares, Mouna Barat‐Houari, Eduardo F. Tizzano, Irene Valenzuela, Quentin Sabbagh, Jill Clayton‐Smith, Adam Jackson, James O’Sullivan, Rebecca Bromley, Siddharth Banka, David Geneviève, Bekim Sadiković

Bibliographic record

VenueGenetics in Medicine · 2024
Typearticle
Languageen
FieldMedicine
TopicPharmacological Effects and Toxicity Studies
Canadian institutionsWestern UniversityLondon Health Sciences Centre
FundersFundació Institut de Recerca Hospital Universitari Vall d’HebronInstitut National de la Santé et de la Recherche MédicaleUniversity of ManchesterManchester Biomedical Research CentreCentre Hospitalier Régional Universitaire de MontpellierGovernment of CanadaGenome CanadaDirectorate for Biological SciencesOntario GenomicsNational Institute for Health and Care ResearchCentre National de la Recherche ScientifiqueOntario Genomics Institute
KeywordsValproic AcidDNA methylationPeripheral bloodMethylationMedicineDNAObstetricsBiologyEpilepsyGeneticsInternal medicinePsychiatryGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.522
Threshold uncertainty score0.245

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.305
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2024
Admission routes2
Has abstractno

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