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Record W4401336690 · doi:10.1007/978-3-031-51089-2_14

Ethics in Pharmacovigilance

2024· book-chapter· en· W4401336690 on OpenAlexaff
Alison Thompson, Ana Komparic

Bibliographic record

Venuenot available
Typebook-chapter
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicPharmacovigilance and Adverse Drug Reactions
Canadian institutionsUniversity of TorontoPublic Health Ontario
Fundersnot available
KeywordsPharmacovigilanceEngineering ethicsMedicinePharmacologyEngineeringDrug

Abstract

fetched live from OpenAlex

Healthcare practitioners play a vital role in facilitating effective and ethical pharmacovigilance, as well as in translating evidence generated through pharmacovigilance activities into clinical practice to improve the care of patients and to improve population health. Physicians, nurses, dentists, pharmacists, and other health practitioners have ethical obligations stemming from their professional obligations to act in their patients’ best interests, to protect and promote the public good, and to maintain their professional competence. In turn, these obligations give rise to a host of ethical principles and considerations related to pharmacovigilance and the safe use of pharmaceuticals. This chapter outlines several of these key principles and considerations, including the fiduciary duty, the duty to protect the public from harm, the duty to maintain professional competence, privacy, consent, disclosure, equity, trust, inclusiveness, the duty to report, scientific integrity, the duty to use the highest quality evidence, and conflicts of interest.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.006
Threshold uncertainty score0.029

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.008
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0030.008
Scholarly communication0.0060.005
Open science0.0010.003
Research integrity0.0040.006
Insufficient payload (model declined to judge)0.0060.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.254
GPT teacher head0.506
Teacher spread0.252 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2024
Admission routes1
Has abstractyes

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