A somatic afterhyperpolarization is driven by ion channel nodes across a Spectrin Polygonal Lattice
Bibliographic record
Abstract
Summary A spectrin-actin cytoskeleton defines the structure of axons and expression of ion channels that support spike propagation, but it is not known how calcium and potassium channels are organized at the soma to control spike output patterns. The hippocampal pyramidal cell slow afterhyperpolarization (sAHP) is generated by a CaRyK protein complex of Cav1.3 calcium, RyR2, and IK potassium channels reflecting an ER-PM junction. Super resolution imaging and dimension reduction identified a highly organized distribution of CaRyK protein clusters aligned as rows with ∼155 nm periodicity that extended to branchpoints to form a non-rigid lattice-like structure across the soma. All CaRyK proteins proved to align and colocalize with the polygonal spectrin βII cytoskeleton. The data indicate that CaRyK proteins at ER-PM junctions that contribute to the sAHP to control the pattern of spike output are distributed with high precision as functional ion channel nodes across the somatic spectrin cytoskeletal network. Graphical Abstract
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.127 | 0.007 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".