HYPR4D Kernel Method With an Unsupervised 2.5SD+0.5TD Deep Learning Assisted Kernel Matrix
Bibliographic record
Abstract
We describe a deep learning (DL) assisted HYPR4D kernelized reconstruction which produces low-noise voxel-level time-activity-curves (TACs) while preserving quantification within small structures as well as consistent spatiotemporal patterns/features within measured data. The proposed method consists of the following advantages over other methods: 1) unsupervised single subject network training scheme independent of positron emission tomography (PET) tracers; 2) training data generated on-the-fly during reconstruction; 3) intrinsic spatiotemporal consistency provided by minimizing the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$L_{2}$ </tex-math></inline-formula> loss using pseudo 4-D (i.e., 2.5 Spatial Dimension + 0.5 Temporal Dimension or 2.5SD+0.5TD) patches between kernelized OSEM subset estimates; and 4) a final tuning step which minimizes over-smoothing from the network output within the kernel matrix. Contrast phantom, human [18F]FDG and [11C]RAC data acquired on GE SIGNA PET/MR were used for evaluations. The proposed DL HYPR4D kernel method outperformed the standard HYPR4D kernel method as well as TOF-OSEM and TOF-BSREM (Q.Clear) in terms contrast recovery versus noise. The proposed final tuning reduced the underestimation bias due to over-smoothing within a 4-mm target structure from ~15% to ~2% while maintaining low-noise voxel-level TACs. In addition, the proposed unsupervised DL assisted reconstruction also outperformed the supervised DL version in terms of bias reduction along the TACs and kinetic model fittings.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".