Cognitive Motor Dissociation in Disorders of Consciousness

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Full frame distilled prediction

Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

Candidate categories

none

Consensus categories

none

Domain

Candidate signal: noneConsensus signal: none

Study design

Candidate signal: Other designConsensus signal: none

Genre

Candidate signal: EmpiricalConsensus signal: Empirical

Teacher disagreement score

0.859

Threshold uncertainty score

0.362

Validation status

machine_predicted_unvalidated · codex-gemma-dda1882f352a

Codex and Gemma teacher scores by category

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Teacher spread

0.324 · how far apart the two teachers sit on this one work

Validation status

score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

BACKGROUND: Patients with brain injury who are unresponsive to commands may perform cognitive tasks that are detected on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). This phenomenon, known as cognitive motor dissociation, has not been systematically studied in a large cohort of persons with disorders of consciousness. METHODS: In this prospective cohort study conducted at six international centers, we collected clinical, behavioral, and task-based fMRI and EEG data from a convenience sample of 353 adults with disorders of consciousness. We assessed the response to commands on task-based fMRI or EEG in participants without an observable response to verbal commands (i.e., those with a behavioral diagnosis of coma, vegetative state, or minimally conscious state-minus) and in participants with an observable response to verbal commands. The presence or absence of an observable response to commands was assessed with the use of the Coma Recovery Scale-Revised (CRS-R). RESULTS: Data from fMRI only or EEG only were available for 65% of the participants, and data from both fMRI and EEG were available for 35%. The median age of the participants was 37.9 years, the median time between brain injury and assessment with the CRS-R was 7.9 months (25% of the participants were assessed with the CRS-R within 28 days after injury), and brain trauma was an etiologic factor in 50%. We detected cognitive motor dissociation in 60 of the 241 participants (25%) without an observable response to commands, of whom 11 had been assessed with the use of fMRI only, 13 with the use of EEG only, and 36 with the use of both techniques. Cognitive motor dissociation was associated with younger age, longer time since injury, and brain trauma as an etiologic factor. In contrast, responses on task-based fMRI or EEG occurred in 43 of 112 participants (38%) with an observable response to verbal commands. CONCLUSIONS: Approximately one in four participants without an observable response to commands performed a cognitive task on fMRI or EEG as compared with one in three participants with an observable response to commands. (Funded by the James S. McDonnell Foundation and others.).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

The record

Venue

New England Journal of Medicine

Topic

Traumatic Brain Injury Research

Field

Medicine

Canadian institutions

not available

Funders

Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute on Disability and Rehabilitation ResearchNational Center for Advancing Translational SciencesMedical Research CouncilIrving Medical Center, Columbia UniversityNational Institutes of HealthCanada Excellence Research Chairs, Government of CanadaUniversité de Recherche Paris Sciences et LettresYale UniversityFondazione Europea Ricerca BiomedicaHangzhou Normal UniversityNational Institute on Disability, Independent Living, and Rehabilitation ResearchMassachusetts General HospitalAssistance publique-Hôpitaux de ParisKoning BoudewijnstichtingGeorgia Clinical and Translational Science AllianceNational Natural Science Foundation of ChinaSorbonne UniversitéDana FoundationInstitut National de la Santé et de la Recherche MédicaleEuropean CommissionFonds De La Recherche Scientifique - FNRSUniversité LavalWeill Cornell Medical CollegeNational Institute for Health and Care ResearchJerold B. Katz FoundationEvelyn TrustJames S. McDonnell FoundationNational Institute of Neurological Disorders and StrokeCenter for Neurotechnology, University of WashingtonUniversity of CambridgeCanadian Institute for Advanced ResearchAgence Nationale de la Recherche

Keywords

Dissociation (chemistry)Functional magnetic resonance imagingElectroencephalographyConsciousness DisordersPsychologyCognitionAudiologyMinimally conscious statePersistent vegetative stateConsciousnessNeuroimagingComa (optics)Resting state fMRILevel of consciousnessMedicinePsychiatryNeuroscienceDevelopmental psychology

Has abstract in OpenAlex

yes

API

/api/v1/works/W4401560861