Bibliographic record
Abstract
Pentameric ligand-gated ion-channels (pLGIC) are neurotransmitter receptors that mediate fast synaptic transmission and muscle contraction in all animals. Ligand binding allows either cations or anions to pass through the post-synaptic cell membrane and induce, or inhibit, muscle contraction, respectively. The pLGIC subunit family traces to before divergence of eukaryotes from prokaryotes and have since expanded to bind to a wide variety of ligands, while retaining a conserved structure. Understanding how the organization and function of pLGIC is regulated and how they evolve between different species is necessary to understand parasite anthelminthic resistance and its relation to model laboratory organisms. Duplication of a homomeric pLGIC, encoded by a single gene, to produce two different homomeric receptors, required an evolved mechanism of subunit exclusion to prevent the descendent gene products combining. This could be through physical, spacial, or temporal separation. Cel-ACR-20 and Cel-ACR-23 are paralogs that form homomeric betaine receptors in C. elegans targeted by the anthelmintic monepantel (MPTL). They are recent orthologs of Hco-mptl-1 , also a homomeric, MPTL sensitive betaine receptor. It is unlikely that ACR-20 and ACR-23 form a heteromer in vivo since MPTL resistance maps to mptl-1 and acr-23 , but not acr-20 . This project investigates the physical interaction between ACR-20 and ACR-23 in Xenopus oocyte electrophysiology through affinity and gating properties of homomeric and heteromeric mixtures and the ability of one truncated subunit to reduce expression of the other.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".