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Record W4402010313 · doi:10.1142/s1793524524501146

Dynamics analysis in a delayed glucose-insulin model incorporating obesity

2024· article· en· W4402010313 on OpenAlex
Chunyan Gao, Fangqi Chen, Pei Yu

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueInternational Journal of Biomathematics · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene Regulatory Network Analysis
Canadian institutionsWestern University
FundersChina Scholarship CouncilNatural Sciences and Engineering Research Council of CanadaNational Natural Science Foundation of China
KeywordsInsulinObesityDynamics (music)MedicineMathematicsInternal medicineComputer sciencePhysics

Abstract

fetched live from OpenAlex

In this paper, the effect of time delay is investigated on the system dynamics of a glucose-insulin model incorporating obesity. Treating the time delay as a bifurcation parameter, the stability switching on the positive equilibrium with global bifurcation is obtained. With the method of normal forms and central manifold theory, the direction and stability of limit cycles arising from Hopf bifurcation are analyzed. Using the method of multiple time scales, the normal form associated with non-resonant double Hopf bifurcation is derived. Moreover, the bifurcations are classified in the two-dimensional parameter plane near the critical point, and numerical simulations are presented to demonstrate the applicability of the theoretical results. Our results indicate that time delay in the glucose-insulin model can not only induce Hopf bifurcation and double Hopf bifurcation but also generate multiple stable periodic solutions. These results may help to understand the dynamical mechanism of glucose-insulin metabolic regulation systems, and to design control strategies for regulating and mitigating the occurrence of related diseases.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.229
Threshold uncertainty score0.505

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.272
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it