Bibliographic record
Abstract
Cells exposed to therapeutic ultrasound-microbubbles (USMB) exhibit a variety of bioeffects such as plasma membrane disruption, enhanced endocytosis, leakage, and apoptosis in response to the USMB-induced stress. Environmental stresses can influence the cell proteome, causing changes in protein expression. This study investigates the effect of USMB on the proteome of AML cells using mass spectrometry. USMB induced notable changes in the cell proteome at both 6 and 24 hrs post treatment, with 77 proteins identified. The USMB parameters also influenced the protein expression with the presence of microbubbles and time, having a significant influence on the magnitude of change as well as the proteins affected. Notable proteins include Annexin A1, S100 A10, A11 and heme oxygenase with average fold changes of 2.60 and 2.40, 1.52 and 1.76, 1.27 and 1.40 and 4.45 and 1.27 at 6 and 24 hrs respectively, post USMB treatment. In addition, the proteins influenced play roles in known cellular responses to the USMB treatment as well as mechanical and oxidative stresses.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".