Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a well-recognised complication of systemic lupus erythematosus (SLE).In one small case series, HLH was noted in approximately 5% of patients with lupus. 1 Differentiating lupus flare from HLH can be challenging, since both can cause fever and cytopenia.A recent review of published literature included studies that combined information about a total of 249 patients with lupus and HLH. 2 HLH episodes were described concomitant with first lupus presentation, at the time of subsequent lupus flare and associated with a secondary triggering infection.Other recognized HLH drivers in people with SLE include drugs, malignancy and pregnancy.Mortality is quoted to be up to 19%. 2 Epidemiological studies show that the number of people diagnosed with HLH of all causes has increased significantly over the last 20 years. 3 This rise is likely multifactorial in origin, in part due to increased recognition and in part due to complications of newer therapies including chimeric antigen receptor (CAR)-T cell therapy, and novel infections such as COVID-19.The risk of HLH in patients with lupus treated with CAR-T cell therapy is not yet known.In recent years there has been the development of international guidelines for the identification, diagnosis and initial management of HLH. 4 5 These guidelines describe a framework to approach any patient unwell with HLH, which include the work-up and rapid diagnosis of lupus as a possible HLH driver.There is a clear focus on the need for cross-speciality working, which is associated with improved outcomes.Managing the patient with HLH complicating lupus involves managing the lupus, any additional trigger, and controlling the secondary HLH related hyperinflammation.This will sometimes require using multiple immunosuppressive therapies in parallel.From the HLH perspective, this may include anakinra, intravenous immunoglobulin, ciclosporin, and in the most unwell patients, etoposide.Prospective trials of managing HLH in patients with SLE are lacking.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it