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Record W4402285270 · doi:10.1016/j.bneo.2024.100040

BIRC5 upregulation enhances DNMT3A-mutant T-ALL cell survival and pathogenesis

2024· article· en· W4402285270 on OpenAlexaff
Wangisa Dunuwille, William C. Wilson, Hassan Bjeije, Nancy Issa, Wentao Han, Tyler M. Parsons, Andrew L. Young, Infencia Xavier Raj, Aishwarya Krishnan, Tarang Gaur, Eunice S. Wang, Andrew P. Weng, Matthew C. Stubbs, Hamza Celik, Amanda F. Cashen, John R. Edwards, Grant A. Challen

Bibliographic record

VenueBlood Neoplasia · 2024
Typearticle
Languageen
FieldMedicine
TopicAcute Lymphoblastic Leukemia research
Canadian institutionsTerry Fox Research InstituteBC Cancer Agency
FundersU.S. National Library of MedicineAmerican Cancer SocietyLeukemia and Lymphoma SocietyNational Cancer InstituteNational Institutes of HealthMemorial Sloan-Kettering Cancer CenterNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteMusculoskeletal Research Center, Washington University in St. LouisGenome Technology Access Center
KeywordsDownregulation and upregulationPathogenesisMutantCell biologyCancer researchChemistryBiologyGeneImmunologyGenetics

Abstract

fetched live from OpenAlex

-mutant T-ALL cells in patient-derived xenografts, positioning BIRC5 as a precision medicine target for these patients.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.092
Threshold uncertainty score0.713

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.270
Teacher spread0.256 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2024
Admission routes1
Has abstractyes

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