In vitro effects of fibrin hydrogel incorporated with Litsea cubeba essential oil on viability of periodontal pathogens and human gingival fibroblasts
Bibliographic record
Abstract
Background/purpose: essential oil (LC-EO) and test its antimicrobial property against key periodontal pathogens and cytotoxicity on human gingival fibroblasts (HGFs). Materials and methods: by the direct contact method. The cytotoxicity to HGFs was determined by MTT assay. Results: was 1.0 % (v/v) and 0.25% (v/v), respectively. The lowest cytotoxicity to HGF cells was observed at 0.0625% (v/v), yielding the cell viability of 73.65 ± 8.24 % at 24 h. Conclusion: Fibrin hydrogel with LC-EO effectively inhibited bacterial growth in a dose-dependent manner. Cytotoxicity assays also revealed concentration-dependent effects on HGF. Our results suggest the potential use of fibrin hydrogel with LC-EO as a novel adjunctive treatment in periodontal diseases.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".