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Record W4402321719 · doi:10.5376/ijmeb.2024.14.0018

Molecular Mechanisms Underlying Mammalian Trait Evolution

2024· article· en· W4402321719 on OpenAlexvenueno aff
Jing He, Jun Li

Bibliographic record

VenueInternational Journal of Molecular Evolution and Biodiversity · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicNutrition, Genetics, and Disease
Canadian institutionsnot available
Fundersnot available
KeywordsTraitEvolutionary biologyBiologyComputational biologyGeneticsComputer science

Abstract

fetched live from OpenAlex

This study systematically reviews the molecular mechanisms underlying mammalian trait evolution, revealing the significant roles of genetic mutations, natural selection, genetic drift, gene flow, and epigenetic modifications in trait evolution. It delves into the roles of genomic innovations such as transcription factors and their regulatory networks, non-coding RNAs, differential gene expression, gene duplication and divergence, horizontal gene transfer, genome rearrangements, as well as key molecular pathways such as signaling pathways, metabolic pathways, and sensory adaptation-related pathways. Through case studies on the evolution of fur and skin pigmentation, mammalian teeth and dietary adaptations, and reproductive strategies and mechanisms, the concrete manifestations of genomic innovation and environmental adaptation in trait evolution are demonstrated. The study also discusses the application of high-throughput sequencing technologies, comparative genomics and phylogenetics, functional genomics, and gene editing technologies (such as CRISPR/Cas9) in evolutionary research, emphasizing the impact of the environment on gene expression and trait evolution. These findings provide profound insights into evolutionary biology and related fields.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.263
Threshold uncertainty score0.553

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.249
Teacher spread0.237 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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Same venueInternational Journal of Molecular Evolution and BiodiversitySame topicNutrition, Genetics, and DiseaseFrench-language works237,207