Coordinate Attention Based 3D-CNN Using Ghost Multi-Scale for Diagnosing Alzheimer’s Disease
Bibliographic record
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease and mild cognitive impairment (MCI) is the early stage of AD. Previous studies have predominantly focused on binary classification using 3 dimensional - convolutional neural network (3D-CNN) for AD diagnosis, with limited progress in multi-classification. Moreover, the current 3D-CNNs often adopt a single-scale architecture with massive parameters growth. Additionally, obtaining precise location information of brain imaging data is crucial for improving the classification accuracy with 3D-CNN. Hence, we propose a multi-scale 3D-CNN based on coordinate attention mechanism to marvelously capture and integrate 3D features with fewer parameters, improving the accuracy of AD diagnosis. A total of 447 cognitively normal (CN), 512 MCI, and 358 AD sMRI images from the Alzheimer's Disease Neuroimaging Initiative datasets are used for multi-class classification task, yielding a classification accuracy of 92.8%. The model merely involves 2.41 M parameters and achieves the best classification results with the least number of parameters when compared to other representative CNN architectures including ResNet 18, ResNet 34, ConvNeXt tiny, and VGG 11. Through the ablation experiment, the addition of attention mechanism and the multi-scale classification enhances the classification performance by 4.5% and 1.5%, respectively. Furthermore, our model outperforms the other six existing studies in terms of accuracy for classifying AD vs. MCI vs. CN. Overall, this study underscores the efficacy of our approach for AD diagnosis, showcasing its utility in diagnosing AD patients and providing novel insights for diagnosing other neurological disorder diseases.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".