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Record W4402401943 · doi:10.5747/cv.2024.v16.v373

A CORRELAÇÃO ENTRE O USO DE ESCITALOPRAM EM IDOSOS E O PROLONGAMENTO DO INTERVALO QT.

2024· article· en· W4402401943 on OpenAlex
Fernanda Cristina Poscai Ribeiro, Luiz Cláudio Behrmann Martins, Giuliana Forte, Bruna Kogici Mohammed Hateem

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueColloquium Vitae · 2024
Typearticle
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsnot available
Fundersnot available
KeywordsEscitalopramMedicinePsychologyPsychiatryAnxiety

Abstract

fetched live from OpenAlex

To achieve the objective of verifying whether there is a correlation between the use of escitalopram in the elderly and QT prolongation, a search was carried out in Pubmed, Scielo and Lilacs. The selected studies were evaluated using the Newcastle-Ottawa scale to assesses study quality. The studies indicate that the link between escitalopram use and serious arrhythmia is weak despite FDA recommendations. The risk of arrhythmia and mortality associated with escitalopram also decreased over time. Cardiac comorbidities increase the risk of QT prolongation and mortality, and modifiable risk factors like hypokalemia and drug interactions should be addressed in at-risk individuals. Healthcare providers face a difficult decision regarding dosage restrictions and medication switching, taking into account escitalopram's effectiveness and tolerability. More research and awareness are needed to optimize antidepressant therapy for cardiac safety.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.235
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.278
Teacher spread0.255 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it