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Record W4402507456 · doi:10.1021/acs.organomet.4c00314

Direct Detection of Pt(IV) Phenyl Complexes upon Intermolecular Oxidative Addition of Aryl Halides and Selective Csp<sup>3</sup>–I versus Csp<sup>2</sup>–Csp<sup>3</sup> and Csp<sup>3</sup>–Csp<sup>3</sup> Bonds Reductive Elimination from N-Heterocyclic Carbene Pt(IV) Phenyl Complexes

2024· article· en· W4402507456 on OpenAlexafffund
Nan Zhang, Weiying He, Kristof M. Altus, Brian O. Patrick, Benjamin S. Gelfand, Pierre Kennepohl, Jennifer A. Love

Bibliographic record

VenueOrganometallics · 2024
Typearticle
Languageen
FieldChemistry
TopicCatalytic C–H Functionalization Methods
Canadian institutionsUniversity of CalgaryUniversity of British Columbia
FundersNatural Sciences and Engineering Research Council of CanadaUniversity of British ColumbiaUniversity of Calgary
KeywordsChemistryArylOxidative additionHalideIntermolecular forceMedicinal chemistryStereoselectivityOrganic chemistryMoleculeCatalysisAlkyl

Abstract

fetched live from OpenAlex

Reaction of a chelating N-heterocyclic carbene Pt(II) dimethyl complex with phenyl iodide and excess KI results in the direct detection of a Pt(IV) phenyl intermediate by 1 H NMR spectroscopy. This finding provides experimental evidence that the reaction between Pt(II) dimethyl complexes and aryl halides proceeds via a concerted oxidative addition (OA) mechanism. Additionally, we report on the selective reductive elimination (RE) of Csp 3 –I vs Csp 2 –Csp 3 and Csp 3 –Csp 3 bonds. Lastly, OA, different RE pathways, and reactivity of different isomers were investigated by computational methods that are consistent with experimental observations. We believe that these results have important implications for the development of new Pt-catalyzed transformations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.263
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2024
Admission routes2
Has abstractyes

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