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Record W4402540940 · doi:10.1093/jas/skae234.210

161 Development, deployment, and calibration of genomic selection tools to improve performance traits for Canadian beef cattle

2024· article· en· W4402540940 on OpenAlexaffabout
Changxi Li, J. A. Basarab, Tiago S. Valente, Graham Plastow, Paul Stothard, Yining Wang, Michael Vinsky

Bibliographic record

VenueJournal of Animal Science · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic and phenotypic traits in livestock
Canadian institutionsUniversity of AlbertaAgriculture and Agri-Food Canada
Fundersnot available
KeywordsBeef cattleGenomic selectionSelection (genetic algorithm)Software deploymentCalibrationBiotechnologyBiologyAnimal scienceComputer scienceStatisticsMathematicsGeneticsGenotypeArtificial intelligenceGeneSingle-nucleotide polymorphismSoftware engineering

Abstract

fetched live from OpenAlex

Abstract Genomic selection has the potential to accelerate the genetic improvement rate for difficult/expensive to measure traits such as feed efficiency and fertility traits in beef cattle. To develop genomic selection tools for Canadian beef cattle, we collected or sourced phenotypic data of feed efficiency along with other traits including carcass merit, female feed intake and fertility related traits, and their genotypes from both research and commercial herds. The phenotypic data were consolidated and recorded for contemporary groups, leading to the development of data sets including 11,292 beef cattle with residual feed intake, dry matter intake, average daily gain, metabolic body weight, 7,299 to 8,081 cattle with carcass merit traits, and 1,802 to 2,792 cows with feed intake and fertility traits after quality controls. Genotype data of the animals from various single nucleotide polymorphisms (SNP) panels were merged to the same allele format of 50K, and then imputed to 770K SNPs, and eventually to whole genome sequence variants. The refined Canadian beef cattle data sets have not only allowed us to investigate genetic architectures of the beef performance traits but also enabled the development of genomic selection tools including molecular breeding values and multiple trait selection indexes with a moderate to moderately high accuracy for the traits through a cross-validation of within reference data set. The genomic selection tools have been successfully deployed to over 10,415 breeding candidates submitted by Canadian beef producers through multiple demonstration projects. The average accuracy of the molecular breeding values and multiple trait selection index of the commercial beef cattle ranged from 0.38 to 0.49 for feed efficiency and carcass merit traits, and from 0.26 to 0.38 for female feed intake and fertility traits. Current research is focusing on calibrating the genomic selection tools with larger data sets and with more advanced genomic prediction methods.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.304
Threshold uncertainty score0.611

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.007
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0020.003
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.252
Teacher spread0.237 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes2
Has abstractyes

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