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Record W4402568580 · doi:10.1002/hem3.70004

Therapeutic strategies and treatment sequencing in patients with chronic lymphocytic leukemia: An international study of ERIC, the European Research Initiative on CLL

2024· article· en· W4402568580 on OpenAlexaboutno aff
Thomas Chatzikonstantinou, Lydia Scarfò, Eva Minga, Georgios Karakatsoulis, Dimitra Chamou, Jana Kotašková, Gloria Iacoboni, Christos Demosthenous, Elisabetta Albi, Miguel Alcoceba, Salem Al‐Shemari, Thérèse Aurran‐Schleinitz, Francesca Bacchiarri, Sofia Chatzileontiadou, Rosa Collado, Zadie Davis, Marcos Daniel de Deus Santos, Maria Dimou, Е. А. Дмитриева, David Donaldson, Gimena dos Santos, Barbara Dreta, Maria Efstathopoulou, Shaimaa El‐Ashwah, Alicia Enrico, Andrzej Frygier, Sara Galimberti, Andrea Galitzia, Eva Gimeno, Valerio Guarente, Romain Guièze, Sean Harrop, Eleftheria Hatzimichael, Yair Herishanu, José‐Ángel Hernández‐Rivas, Ozren Jakšić, Elżbieta Kalicińska, Kamel Laribi, Volkan Karakuş, Arnon P. Kater, Bonnie Kho, Maria Kislova, Εliana Konstantinou, Maya Koren‐Michowitz, Ιoannis Kotsianidis, Zuzana Kubová, Jorge Labrador, Deepesh Lad, Luca Laurenti, Thomas Longval, Alberto López‐García, Juan Marquet, Stanislava Mašlejová, Carlota Mayor‐Bastida, Biljana Mihaljević, Ivana Milošević, Fátima Mirás, Riccardo Moia, Marta Morawska, Uttam Kumar Nath, Almudena Navarro‐Bailón, Jacopo Olivieri, Irina Panovska‐Stavridis, Maria Papaioannou, Cheyenne Pierie, Anna Puiggros, Gianluigi Reda, Gian Matteo Rigolin, Rosa Ruchlemer, Mattia Schipani, Annett Schiwitza, Yandong Shen, Tereza Shokralla, Martin Šimkovič, Svetlana Smirnova, Dina Sameh Soliman, Stephan Stilgenbauer, Tamar Tadmor, Kristina Tomić, Eric Tse, Theodoros P. Vassilakopoulos, Andrea Visentin, Candida Vitale, George Vrachiolias, Vojin Vuković, Renata Walewska, Zhenshu Xu, Münci Yağcı, Lucrecia Yáñez, Mohamed A. Yassin, Jana Zuchnická, David Oscier, Alessandro Gozzetti, Panagiotis Panagiotidis, Francesc Bosch, Paolo Sportoletti, Blanca Espinet, Gerassimos A. Pangalis, Viola Maria Popov, Stephen P. Mulligan, Maria K. Angelopoulou, Fatih Demırkan, Tomáš Papajík, Bella Biderman, Roberta Murru, Marta Coscia, Constantine S. Tam, Antonio Cuneo, Gianluca Gaïdano, Rainer Claus, Niki Stavroyianni, Livio Trentin, Darko Antić, Lukáš Smolej, Olga Kalashnikova, Mark Catherwood, Martin Špaček, Šárka Pospı́šilová, Michael Doubek, Eugene Nikitin, Anastasia Chatzidimitriou, Paolo Ghia, Κώστας Σταματόπουλος

Bibliographic record

VenueHemaSphere · 2024
Typearticle
Languageen
FieldMedicine
TopicChronic Lymphocytic Leukemia Research
Canadian institutionsnot available
FundersServierGenesis PharmaAssociazione Italiana per la Ricerca sul CancroMinisterstvo Zdravotnictví Ceské RepublikyIncyteBeiGeneGenentechSunesisGilead SciencesAbbVieEuropean CommissionSanofiCilagTG TherapeuticsAmgenMinistero della SalutePfizerCelgeneAstraZenecaEli Lilly and CompanyBristol-Myers Squibb
KeywordsChronic lymphocytic leukemiaMedicineOncologyInternal medicineLeukemia

Abstract

fetched live from OpenAlex

Barplots representing the percentage of patients treated with different regimens.(A) In second line, before and after 2014, (B) in third line, before and after 2014, (C) in fourth and subsequent lines, before and after 2014, (D) in second line, including only patients with an early (<24 months) need for second line treatment after 2016.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.005
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.003
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.099
GPT teacher head0.367
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2024
Admission routes1
Has abstractyes

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