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Exploration Of Muscle Motor Control To Guide Botox Injections For Runner’s Dystonia

2024· article· en· W4402663006 on OpenAlexaboutno aff
Kellee Harper-Hanigan, Emma Boughner, Summer Morris, Katie Robinson, Allison H. Gruber

Bibliographic record

VenueMedicine & Science in Sports & Exercise · 2024
Typearticle
Languageen
FieldMedicine
TopicBotulinum Toxin and Related Neurological Disorders
Canadian institutionsnot available
Fundersnot available
KeywordsDystoniaPhysical medicine and rehabilitationMotor controlControl (management)MedicineNeurosciencePsychologyComputer scienceArtificial intelligence

Abstract

fetched live from OpenAlex

HISTORY: The patient (female, age 44) was diagnosed with runner’s dystonia (RD) of the right lower extremity (LE) in April 2022. RLE heel whip emerged in 2016 during a race. Notable medical history includes severe traumatic brain injury at age 4 and from 2017-2021: abdominal muscle diastasis (DRAM) postpartum, PT treatment of DRAM, abdominoplasty to correct DRAM and steroid injection for mild right hip dysplasia. Botox injection to R tensor fascia lata received in July 2022 did not resolve RD symptoms, which has increased in severity and now impact walking and cycling. PHYSICAL EXAMINATION: The patient completed the following tests in June 2023 to guide future Botox interventions: Lower Extremity Functional Scale (LEFS), LE strength and coordination, upper (UMN) and lower motor neuron (LMN) screen, McGill’s torso muscular endurance test battery for endurance, and treadmill running gait analysis with bilateral surface electromyography (EMG) of the medial gastrocnemius, tibialis anterior, biceps femoris, and gluteus maximus. Neuromuscular effort was calculated as the time duration spent in, above, and below the activation measured during maximum voluntary contraction during the stance phase of running. DIFFERENTIAL DIAGNOSIS: Genetic testing ruled out Parkinson's-related diseases. MRI and EMG screening ruled out multiple sclerosis. TEST AND RESULTS: UMN/LMN screen was negative. LEFS score = 70/80. Mild gross strength deficits in right hip external rotators, hip abductors, and ankle plantarflexors as compared with left. McGills’s test confirmed low endurance of back extensors. Neuromuscular effort of tibialis anterior and gluteus maximus during running was greater in right compared with left. FINAL WORKING DIAGNOSIS: The patient meets the following RD clinical assessment criteria: task specificity, first onset of symptoms during running, inconsistent orthopedic examination, negative UMN/LMN exam, absence of pain, and excessive muscle activation observed with EMG. TREATMENT AND OUTCOMES: The patient agreed to back extensor and hip muscle strengthening exercises. Abnormal running gait mechanics may benefit from biofeedback gait retraining due to muscular imbalances resulting in poor motor control. Botox injections could be explored, but risks, benefits and patient preference must be considered.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.000
Science and technology studies0.0010.000
Scholarly communication0.0000.001
Open science0.0010.000
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0070.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.313
Teacher spread0.289 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2024
Admission routes1
Has abstractyes

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