P.273: Recurrence of cryocrystalglobulinemia after kidney transplant: Case report.
Bibliographic record
Abstract
There are only case reports published on cryocrystalgloublinemia, as it is a rare disorder characterized by immunoglobulin assembly into crystalline arrays with associated thrombosis, ischemia and infarction leading to multi-organ failure. We present a case of a 76-year-old male with end stage renal disease secondary to bilateral renal artery occlusion as a thrombotic manifestation of cryocrystalgloublinemia who underwent renal transplantation in 2009. The patient presented with levido reticularis, digitial ischemia, heart failure and acute kidney injury in 2023 with recurrent cryocrystalgobulinemia diagnosed on renal allograft biopsy. The patient also had coincident recurrent IgG kappa paraproteinemia, which had previously resolved following a bone marrow transplant conducted in 2008 prior to his kidney transplant. For treatment of the recurrent cryocrystalglobulinemia post-transplant, the patient received plasmapheresis and pulse methylprednisolone therapy with no improvement in his clinical manifestations. He ultimately passed away from complications of his disease prior to initiation of any further immunosuppressive therapy. To our knowledge, this is the first reported case of recurrent cryocrystalglobulinemia following renal transplantation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".