FpCBS is important for H2S production and plant infection in Fusarium pseudograminearum
Bibliographic record
Abstract
Crown rot caused by Fusarium pseudograminearum remains a significant global challenge to wheat production. In this study, the role of FpCBS in F. pseudograminearum were investigated by creating deletion mutants and assessing their impacts on hydrogen sulfide (H 2 S) production, oxidative stress adaptation, and pathogenicity, supported by transcriptomic and metabolomic analyses. Deletion of FpCBS resulted in a significant reduction in H 2 S production, accompanied by increased levels of homocysteine and cysteine, suggesting the importance of FpCBS for H 2 S biosynthesis. Furthermore, Δ Fpcbs mutants displayed diminished pathogenicity and decreased resistance to H 2 O 2 . Also, Δ Fpcbs mutants correlated with reduced catalase activity. Transcriptomic data revealed altered gene expression related to oxidative stress and virulence, including genes encoding cell wall-degrading enzymes, mycotoxins, and polyketides. Altogether, we proposed that F. pseudograminearum uses CBS-dependent H 2 S production to facilitate host infection, adaptation to host-induced oxidative stress, and synthesis of virulence factors. These findings highlight the potential of FpCBS as a novel target for developing strategies to control wheat crown rot.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".