FpCBS is important for H2S production and plant infection in Fusarium pseudograminearum
Bibliographic record
Abstract
Crown rot caused by Fusarium pseudograminearum remains a significant global challenge to wheat production. In this study, the role of FpCBS in F. pseudograminearum were investigated by creating deletion mutants and assessing their impacts on hydrogen sulfide (H 2 S) production, oxidative stress adaptation, and pathogenicity, supported by transcriptomic and metabolomic analyses. Deletion of FpCBS resulted in a significant reduction in H 2 S production, accompanied by increased levels of homocysteine and cysteine, suggesting the importance of FpCBS for H 2 S biosynthesis. Furthermore, Δ Fpcbs mutants displayed diminished pathogenicity and decreased resistance to H 2 O 2 . Also, Δ Fpcbs mutants correlated with reduced catalase activity. Transcriptomic data revealed altered gene expression related to oxidative stress and virulence, including genes encoding cell wall-degrading enzymes, mycotoxins, and polyketides. Altogether, we proposed that F. pseudograminearum uses CBS-dependent H 2 S production to facilitate host infection, adaptation to host-induced oxidative stress, and synthesis of virulence factors. These findings highlight the potential of FpCBS as a novel target for developing strategies to control wheat crown rot.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".