Characterizing Normal and Tumour Blood Microcirculatory Systems Using Optical Coherence Tomography
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Blood vessels transport blood and deliver essential molecules to cells. In cancer, the tumour vasculature evolves very differently from healthy tissue, not only in morphology but also in functionality. Comprehensive 3D in vivo imaging of the tumour microcirculatory system thus might lead to a clearer understanding of the vascular role in tumour growth and response to cancer therapy. Here, we employed two optical coherence tomography (OCT) extensions, speckle-variance and Doppler, to study the microvascular architecture and blood flow in normal murine and xenograft tumour tissue. We explored the biophysics of blood flow in microcirculation and extracted relevant quantification features such as vessel diameters and velocity histograms, and combined diameter–velocity plots. It was demonstrated that tumour microcirculation evolves in time and differs from healthy tissue, impacting tumour growth kinetics. This proof-of-principle study demonstrates the potential of OCT to provide an understanding of the temporal evolution of the tumour vasculature and its relationship with tumour development.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it