Management of Hereditary Angioedema Type 1 and 2 for Canadian Allergy and Immunology Practitioners
Bibliographic record
Abstract
It is imperative for allergists and immunologists to accurately confirm the diagnosis of HAE and coordinate individualized, patient-centred treatment. The 2019 International/Canadian Hereditary Angioedema Guideline, provides an evidence-based approach to managing HAE patients. The objective of this article is to further assist healthcare providers in caring for patients with a confirmed diagnosis of HAE by outlining an approach to patient counselling and reviewing the principles of therapy. We propose 5 essential items to consider in the management of all HAE patients: 1) Patient education; 2) On-demand therapy; 3) Short-term prophylaxis (STP); 4) Long-term prophylaxis (LTP); and 5) Genetic testing. We will also discuss special considerations for pregnant patients.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".