Prognostic role of persistent angina after percutaneous revascularization in chronic coronary syndrome with altered angiography and stress CMR
Bibliographic record
Abstract
In patients with established chronic coronary syndrome (CCS), the significance of persistent angina is controversial. We aimed to evaluate the prognostic role of persistent angina in symptomatic CCS patients with abnormal stress cardiovascular magnetic resonance (CMR) and altered angiographic findings undergoing percutaneous revascularization. We analyzed 334 CCS patients with Canadian Cardiovascular Society angina class ≥ 2, perfusion deficits on stress CMR and severe lesions in angiography who underwent medical therapy optimization plus CMR-guided percutaneous revascularization. We investigated the association of persistent angina at 6 months postintervention with subsequent cardiac death, myocardial infarction, and hospital admission. All patients had angina class ≥ 2 (mean: 2.8 ± 0.7), abnormal stress CMR (mean ischemic burden: 5.8 ± 2.7 segments), and severe angiographic lesions. The angina resolution rates were 81% at 6 months, and 81%, 81%, and 77% at 1, 2, and 5 years, respectively. During a median follow-up of 8.9 years, persistent angina was independently associated with higher rates of subsequent cardiac death (13% vs 4%; HR, 3.7; 95%CI, 1.5-9.2; P = .005), myocardial infarction (24% vs 6%; HR, 4.9; 95%CI, 2.4–9.9; P < .001), and hospital admission for heart failure (27% vs 13%; HR, 2.7; 95%CI, 1.5–5.2; P = .001). In CCS patients with robust diagnostic evidence from symptoms, stress CMR, and angiography, persistent angina after percutaneous revascularization is a strong predictor of subsequent cardiac death, myocardial infarction, and hospital admission for heart failure. En pacientes con síndrome coronario crónico (SCC) establecido, el significado de la angina persistente es controvertida. Se evaluó la utilidad pronóstica de la angina persistente en pacientes sintomáticos con SCC y resonancia magnética cardiaca (RMC) de estrés y angiografía alteradas sometidos a revascularización percutánea. Se analizó a 334 pacientes con SCC con angina de grado ≥ 2 de la Sociedad Canadiense de Cardiología, déficit de perfusión en la RMC de estrés y lesiones graves en la angiografía remitidos para optimización del tratamiento médico y revascularización percutánea guiada por RMC. Se investigó la asociación de la angina persistente a los 6 meses tras la intervención con los eventos muerte cardiaca, infarto e insuficiencia cardiaca. Todos los pacientes presentaban angina de grado ≥ 2 (media, 2,8 ± 0,7), RMC de estrés anómala (5,8 ± 2,7 segmentos isquémicos) y lesiones angiográficas graves. La tasa de resolución de la angina fue del 81% a los 6 meses y del 81, el 81 y el 77% tras 1, 2 y 5 años respectivamente. Durante una mediana de seguimiento de 8,9 años, la angina persistente se asoció con más muerte cardiaca (el 13 frente al 4%; HR = 3,7; IC95%, 1,5-9,2; p = 0,005), infarto (el 24 frente al 6%; HR = 4,9; IC95%, 2,4-9,9; p < 0,001) e insuficiencia cardiaca (el 27 frente al 13%; HR = 2,7; IC95%, 1,5-5,2; p = 0,001). En pacientes con SCC y pruebas diagnósticas firmes de síntomas, RMC de estrés y angiografía, la angina persistente tras la revascularización percutánea es un potente predictor de muerte cardiaca, infarto de miocardio e ingreso por insuficiencia cardiaca.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".