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Record W4403163014 · doi:10.1177/19322968241275701

The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors

2024· article· en· W4403163014 on OpenAlex
David C. Klonoff, Guido Freckmann, Stefan Pleus, Boris Kovatchev, David Kerr, Chui Tse, Chengdong Li, Michael S. D. Agus, Kathleen Dungan, Barbora Voglová Hagerf, Jan S. Krouwer, Wei-An Lee, Shivani Misra, Sang Youl Rhee, Ashutosh Sabharwal, Jane Jeffrie Seley, Viral N. Shah, Nam K. Tran, Kayo Waki, Chris Worth, Tiffany Tian, Rachel E. Aaron, Keetan Rutledge, Cindy Ho, Alessandra T. Ayers, Amanda Adler, David Ahn, Halis Kaan Aktürk, Mohammed E. Al‐Sofiani, Timothy S. Bailey, Matt Baker, Lia Bally, Raveendhara R. Bannuru, Elizabeth M Bauer, Yong Mong Bee, Julia E. Blanchette, Eda Cengiz, J. Geoffrey Chase, Kong Y. Chen, Daniel R. Cherñavvsky, Mark A. Clements, Gerard L. Coté, Ketan Dhatariya, Andjela Drincic, Niels Ejskjær, Juan Espinoza, Chiara Fabris, G. Alexander Fleming, Mônica Andrade Lima Gabbay, Rodolfo J. Galindo, Ana María Gómez Medina, Lutz Heinemann, Norbert Hermanns, Thanh D. Hoang, Sufyan Hussain, Peter G. Jacobs, Johan Jendle, Shashank Joshi, Suneil K. Koliwad, Rayhan Lal, Lawrence A. Leiter, Marcus Lind, Julia K. Mader, Alberto Maran, Umesh Masharani, Nestoras Mathioudakis, Michael J. McShane, Chhavi Mehta, Sun Joon Moon, James H. Nichols, David N. O’Neal, Francisco J. Pasquel, Anne L. Peters, Andreas Pfützner, Rodica Pop‐Busui, Pratistha Ranjitkar, Connie M. Rhee, David B. Sacks, Signe Schmidt, Simon M. Schwaighofer, Bin Sheng, Gregg D. Simonson, Koji Sode, Elias K. Spanakis, Nicole L. Spartano, Guillermo E. Umpierrez, Maryam Vareth, Hubert W. Vesper, Jing Wang, Eugene E. Wright, Alan H.B. Wu, Sewagegn Yeshiwas, Mihail Zilbermint, Michael A. Kohn

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueJournal of Diabetes Science and Technology · 2024
Typearticle
Languageen
FieldMedicine
TopicHyperglycemia and glycemic control in critically ill and hospitalized patients
Canadian institutionsUniversity of TorontoSt. Michael's Hospital
FundersMannKind CorporationUniversity of California, DavisCenters for Disease Control and PreventionRoche Diabetes CareSanofiNational Institute of Diabetes and Digestive and Kidney DiseasesNIHR Imperial Biomedical Research CentreCardinal HealthTandem Diabetes CareNovo NordiskNational Institute for Health and Care ResearchDexcomInsulet CorporationWellcome TrustU.S. Department of DefenseEli Lilly and CompanyAgency for Toxic Substances and Disease RegistryAstraZenecaNovo Nordisk FondenNational Center for Advancing Translational SciencesLeona M. and Harry B. Helmsley Charitable TrustU.S. Department of Veterans AffairsU.S. Department of Health and Human ServicesAbbott Diabetes CareNational Science Foundation
KeywordsDiabetes mellitusContinuous glucose monitoringBlood Glucose Self-MonitoringGridComputer scienceMedicineData scienceType 1 diabetesEndocrinologyMathematics

Abstract

fetched live from OpenAlex

INTRODUCTION: An error grid compares measured versus reference glucose concentrations to assign clinical risk values to observed errors. Widely used error grids for blood glucose monitors (BGMs) have limited value because they do not also reflect clinical accuracy of continuous glucose monitors (CGMs). METHODS: Diabetes Technology Society (DTS) convened 89 international experts in glucose monitoring to (1) smooth the borders of the Surveillance Error Grid (SEG) zones and create a user-friendly tool-the DTS Error Grid; (2) define five risk zones of clinical point accuracy (A-E) to be identical for BGMs and CGMs; (3) determine a relationship between DTS Error Grid percent in Zone A and mean absolute relative difference (MARD) from analyzing 22 BGM and nine CGM accuracy studies; and (4) create trend risk categories (1-5) for CGM trend accuracy. RESULTS: The DTS Error Grid for point accuracy contains five risk zones (A-E) with straight-line borders that can be applied to both BGM and CGM accuracy data. In a data set combining point accuracy data from 18 BGMs, 2.6% of total data pairs equally moved from Zones A to B and vice versa (SEG compared with DTS Error Grid). For every 1% increase in percent data in Zone A, the MARD decreased by approximately 0.33%. We also created a DTS Trend Accuracy Matrix with five trend risk categories (1-5) for CGM-reported trend indicators compared with reference trends calculated from reference glucose. CONCLUSION: The DTS Error Grid combines contemporary clinician input regarding clinical point accuracy for BGMs and CGMs. The DTS Trend Accuracy Matrix assesses accuracy of CGM trend indicators.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.549
Threshold uncertainty score0.798

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.002
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.308
Teacher spread0.298 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it