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Record W4403173857 · doi:10.1101/2024.10.05.24314933

Outbreak of <i>Leishmania tropica</i> amongst militia members in a non-endemic district under conflict in the lowlands of Somali Region in Ethiopia

2024· preprint· en· W4403173857 on OpenAlexaff
Adugna Abera, Henok Tadesse, Dereje Beyene, Desalegn Geleta, Ebise Abose, Solomon Kinde, Mussie Abdosh, Hailemariam Difabachew, Mahlet Belachew, Abdulahi Gire, Tesfahun Bishaw, Medhanye Habtetsion, Zelalem Olani, Endawoke Eyelachew, Worku Birhanu, Kaoutar Choukri, Jasmine Coppens, Gemechu Tadese, Kebron Haile, Henok Bekele, Melkamu Abte, Getachew Tollera, Mesay Hailu, Zeyede Kebede, Gert Van der Auwera, Fikre Seife, Jean‐Claude Dujardin, Johan van Griensven, Dawit Wolday, Wendemagegn Embiale, Myrthe Pareyn, Geremew Tasew

Bibliographic record

VenuemedRxiv · 2024
Typepreprint
Languageen
FieldSocial Sciences
TopicAfrican studies and sociopolitical issues
Canadian institutionsMcMaster UniversityPopulation Health Research Institute
Fundersnot available
KeywordsSomaliOutbreakGeographyLeishmania tropicaSocioeconomicsVirologyMedicineSociologyLeishmaniasisCutaneous leishmaniasis

Abstract

fetched live from OpenAlex

Abstract Following the emergence of a conflict, an outbreak of cutaneous leishmaniasis (CL) occurred in a non- endemic lowland area in the Somali Region in Ethiopia, raising public health concerns. All 1050 patients were militia members, immunologically naïve and displaced into a conflict area with a likely sylvatic transmission cycle. We identified Leishmania tropica as the causative species, challenging the previous assumption that L. aethiopica was Ethiopia’s primary agent of CL. Notably, over 77% of patients had more than 10 lesions, a presentation atypical for L. tropica elsewhere. Phlebotomus orientalis and P. sergenti , vectors for visceral leishmaniasis (VL) and CL in North Africa respectively, were captured. Further research is needed to explore the eco-epidemiology of the outbreak and the patient’s treatment responses. Insights will help develop management strategies to control this newly emerging form of CL, prevent its spread to other regions, and hybridize with Leishmania strains causing VL endemic.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.040
Threshold uncertainty score0.988

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.037
GPT teacher head0.325
Teacher spread0.288 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2024
Admission routes1
Has abstractyes

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