Prediction of Peak-to-Peak Pressure Gradient in Patients with Aortic Coarctation Using Physics-Informed Neural Networks
Bibliographic record
Abstract
Even after early repair of aortic coarctation (AoCo), life expectancy is reduced due to complications such as hypertension. Invasive diagnostic catheterization is used to evaluate peak-to-peak pressure gradients (PGpp) across the CoAo. Clinically significant PGppare those greater than 20 mmHg under resting conditions, in which case the patient is referred for a second intervention to repair the CoAo. In this study, we demonstrate the feasibility of using Physics-Informed Neural Networks (PINNs) to predict PGppin patients with AoCo non-invasively, based on images obtained from cardiac magnetic resonance imaging. We analyzed a group of 3 patients with CoAo under resting and pharmacological stress conditions. We were able to obtain PGppvalues very close to the actual values obtained by diagnostic catheterization, with an absolute error and average percentage error of 0.57 mmHg and 8.29% for the resting condition, and 4.13 mmHg and 8.63% for the pharmacological stress condition. Our method also successfully identified the only patient who presented a clinically significant PGppunder resting conditions, with differences of less than 1 mmHg.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".