Efficacité de 6 scénarios de décontamination de bras de fauteuils contaminés volontairement au cyclophosphamide
Bibliographic record
Abstract
RÉSUMÉ Contexte : Les bras de fauteuils en clinique externe d’oncologie sont fréquemment contaminés au cyclophosphamide. Objectif : Évaluer l’efficacité de scénarios de décontamination. Méthodologie : Il s’agit d’une étude descriptive de type simulation de 6 scénarios de décontamination d’une surface de tissu en silicone contaminée avec 10 µg de cyclophosphamide. Les produits de décontamination testés (ammonium quaternaire, peroxyde d’hydrogène 0,5 %, détergent 0,005 % et hypochlorite de sodium 0,5 %) ont été utilisés avec des lingettes de microfibres. La contamination résiduelle a été mesurée à l’aide d’un système de chromatographie liquide ultra- performante et de spectrométrie de masse en tandem, avec des limites de détection et de quantification du cyclophosphamide identiques (0,0006 ng/cm2). Résultats : Parmi les 59 échantillons, 3 blancs étaient négatifs, 5 ont permis la mesure du taux de récupération (93,7 ± 4,6 % [écart-type]) et 51 étaient expérimentaux. L’efficacité moyenne des agents était supérieure ou égale à 99,79 %. Quel que soit l’agent utilisé, l’efficacité était de 99,30 ± 1,20 % après un seul nettoyage (n = 18), 99,90 ± 0,15 % après 2 (n = 18) et 99,95 ± 0,06 % après 3 (n = 15). Conclusions : Six scénarios de décontamination se sont avérés efficaces. La répétition du nettoyage a augmenté de façon marginale l’efficacité de la décontamination. Mots-clés : cyclophosphamide, décontamination, simulation ABSTRACT Background: The arms of chairs in outpatient oncology clinics are frequently contaminated with cyclophosphamide.Objective: To evaluate the effectiveness of decontamination scenarios. Methods: This was a descriptive simulation-type study of 6 decontamination scenarios of a silicone fabric surface contaminated with 10 µg of cyclophosphamide. The decontamination products tested (quaternary ammonium, 0.5% hydrogen peroxide, 0.005% detergent, and sodium hypochlorite 0.5%) were applied with microfibre wipes. Residual contamination was measured using an ultra-performance liquid chromatography-tandem mass spectrometry system with identical cyclophosphamide detection and quantification limits (0.0006 ng/cm2). Results: Among the 59 samples, 3 blanks were negative, 5 allowed measurement of the recovery rate (93.7% [standard deviation 4.6%]), and 51 were experimental. The average efficiency of the agents was greater than or equal to 99.79%. Regardless of the agent used, effectiveness was 99.30% (SD 1.20%) after 1 cleanse (n = 18), 99.90% (SD 0.15%) after 2 cleanses (n = 18), and 99.95% (SD 0.06%) after 3 cleanses (n = 15). Conclusion: The 6 decontamination scenarios were effective. Repeated cleaning marginally increased the effectiveness of decontamination. Key words: cyclophosphamide, decontamination, simulation
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".