Editorial: Biocompatible hydrogels: properties, synthesis and applications in biomedicine
Bibliographic record
Abstract
It gives us great pleasure to prepare this invited editorial for the Research Topic in Frontiers in Chemistry titled "Biocompatible Hydrogels: Properties, Synthesis and Applications in Biomedicine". Due to the favourable mechanical properties, biocompatibility and biodegradability features, the hydrogels with three-dimensional (3D) networks have displayed great potentials in biomedical applications, including drug delivery and tissue engineering. In recent years, several strategies and techniques on biocompatible polymer constructions and hydrogel preparation have been developed, guaranteeing the biocompatible hydrogels in several biomedical applications, including wound healing, cancer therapy, etc. In this Research Topic, a number of interesting studies were written by 41 authors, related to biocompatible hydrogels and polymeric nano-materials with functional characteristics in tissue engineering and biomedicine applications. Niclosamide has been widely used in treating cancer, viral infections, and metabolic disorders due to its ability to regulate signalling pathways and biological processes. To improve the efficacy of niclosamide, Tai et al. have fabricated niclosamide conjugated microspheres based on poly(lactic-co-glycolic acid) (PLGA) and hyaluronic acid (HA) via microfluidic approach. The obtained microspheres with a drug-loading efficiency of 8.70% displayed a sustained release behavior at pH 7.4 and 5.0, showing a quasi-first-order release kinetic. Furthermore, the niclosamide conjugated microspheres could increase the cellular uptake using Caco-2 cells and the inhibitory effect on Caco-2 cells, showing potential in targeted drug delivery in the intestine. In recent years, cancer immunotherapy using the hydrogels strategies has made significant progress. Liu et al. have synthesized a novel polymer for drug delivery. We believe that the encouraging approaches could advance the biocompatible hydrogels in tissue engineering and drug delivery, as well as for future clinical applications. Once again, we sincerely hope the researchers in related areas will enjoy reading all the papers in this special edition.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".