The Impact of Prophylaxis on the Quality of Life of Boys with Haemophilia—A Twin-centre Study from South India
Bibliographic record
Abstract
Background and Aims: Quality of life (QOL) of boys with haemophilia was severely affected due to many reasons like frequent hospital visits and joint stiffness. This study aims to analyse the impact of the prophylaxis programme on the QOL of haemophiliac boys. Methods: This is a twin-centre cross-sectional study that included all boys with haemophilia aged between 4 and 18 years and receiving prophylaxis. The Canadian Haemophilia Outcome – Kids Life Assessment Tool (CHO-KLAT) Version 3 was used to compare pre-prophylaxis scores with post-prophylaxis scores obtained after four months of prophylaxis. Results: The mean (standard deviation [SD]) age of the study participants was 10.66 (1.28) years. About 88% had haemophilia A and 66.66% had good adherence to prophylaxis. The mean pre-prophylaxis total score was 45.6 (4.9) and the mean post-prophylaxis total score was 64.3 (5.4). Significant improvement in total scores and domain scores was observed in the post-prophylaxis group.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".