Assessment of chitosan-PVA hydrogels infused with marine collagen peptides for potential wound healing applications
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Bibliographic record
Abstract
• Marine collagen peptides (CP) were incorporated into chitosan-PVA hydrogels using non-toxic procedure with no crosslinkers. • Mechanical and biological properties were measured for potential wound-healing activity. • Swelling ratio was high and compressive strength of hydrogels was very good. • Higher PVA amounts did not improve the mechanical properties significantly. • Marine collagen peptide (CP) increased antimicrobial effect and hemostatic properties, yet showed low toxicity. Ideal wound dressings should show enhanced moisture management at the wound site, antibacterial and physical barrier, and mechanical robustness. Additionally, it should be easy to apply to the wound and be biocompatible and non-toxic. In this study, a linker-free freeze-thaw procedure was used to create an array of chitosan/PVA hydrogels blended with commercially available marine collagen peptides. Marine collagen peptides (CP) are easily available as by-products of the marine food industry and are an inexpensive and novel source of biomaterial in this field. The different weight ratios of chitosan, PVA, and CP influenced the hydrogel properties such as swelling, gel content, evaporation, and mechanical properties. Furthermore, SEM and ATR-FTIR were used to characterize the hydrogels generated under ideal conditions. After 24 h, the optimum hydrogel (chitosan:PVA:CP ratio of 1:5:1) showed a water absorption capacity of up to 900 %, a gel content of 80 %, and a 40 % evaporation rate. The physical interactions between marine collagen peptide and gel-forming components were validated by ATR-FTIR spectra, and the hydrogel kept a sufficient porous structure for potential wound dressing application. To test the mechanical integrity of the hydrogels, compression testing was carried out showing a compressive modulus of up to ∼40 kPa. The addition of marine collagen peptide in the chitosan/PVA hydrogel increased its wettability, antimicrobial capabilities, and hemostatic properties. Furthermore, the hydrogel preparation procedure is simple and does not use toxic chemicals, serving as a model for developing safe and effective hydrogel wound dressing.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it