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Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment
Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca, Ewoud van der Lelij, William J. Jagust, Susan Landau, Leslie M. Shaw, Edward B. Lee, Arthur W. Toga, Andrew J. Saykin, Kwangsik Nho, Richard J. Perrin, Duygu Tosun, Erin Drake, Tom Montine, Cat Conti, Rachel L. Nosheny, Diana Truran Sacrey, Juliet Fockler, Melanie J. Miller, Catherine Conti, Winnie Kwang, Chengshi Jin, Miriam T. Ashford, Derek Flenniken, Michael S. Rafii, Rema Raman, Gustavo Jiménez, Michael Donohue, Jennifer Salazar, Andrea Fidell, Virginia Boatwright, Justin Robison, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Taylor Clanton, Elizabeth Shaffer, Caitlin Webb, Lindsey Hergesheimer, Stephanie Smith, Sheila Ogwang, Olusegun Adegoke, Payam Mahboubi, Jeremy Pizzola, Cecily Jenkins, Naomi Saito, Kedir Adem Hussen, Hannatu Amaza, Mai Seng Thao, Shaniya Parkins, Omobolanle Ayo, Matt Glittenberg, Isabella Hoang, Kaori Kubo Germano, Joe Strong, Trinity Weisensel, Fabiola Magana, Lisa Thomas, Vanessa Guzmán, Adeyinka Ajayi, Joseph Di Benedetto, Sandra Talavera, Joel P. Felmlee, Nick C. Fox, Paul M. Thompson, Arvin Forghanian-Arani, Bret Borowski, Calvin Reyes, Caitie Hedberg, Chad Ward, Christopher G. Schwarz, Denise A. Reyes, Jeff Gunter, John Moore-Weiss, Kejal Kantarci, Leonard Matoush, Matthew L. Senjem, Prashanthi Vemuri, Robert I. Reid, Ian B. Malone, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Alexander Knaack, Evan Fletcher, Stephanie Rossi Chen, Mark Choe, Karen Crawford, Paul A. Yushkevich, Sandhitsu R. Das, Robert A. Koeppe, Gil D. Rabinovici, Victor L. Villemagne, Brian J. Lopresti, John N. Morris, Erin Franklin, Haley Bernhardt, Nigel J. Cairns, Lisa Taylor‐Reinwald, Maxwell Lee, Magdalena Korecka, Magdalena Brylska, Yang Wan, John Q. Trojanowki, Scott Neu, Tatiana Foroud, Taeho Jo, Shannon L. Risacher, Hannah Craft, Liana G. Apostolova, Kelly Nudelman, Kelley Faber, Zoë Potter, Kaci Lacy, Rima Kaddurah-Daouk, Li Shen, Jason Karlawish, Claire M. Erickson, Joshua D. Grill, Emily A. Largent, Kristin Harkins, Leon J. Thal, Zaven Kachaturian, Richard Frank, Peter J. Snyder, Neil Buckholtz, Laurie Ryan, Susan Molchan, Zaven S. Khachaturian, María C. Carrillo, William Z. Potter, Marie Bernard, Héctor Alfredo Baptista González, Carole Ho, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Nina Silverberg, Lisa C. Silbert, Jeffrey Kaye, Sylvia S. White, Aimee Pierce, Amy Thomas, Tera Clay, Daniel L. Schwartz, G. Devereux, Janet Taylor, Jennifer Ryan, Mike Nguyen, Madison DeCapo, Yanan Shang, Lon S. Schneider, Cynthia Muñoz, Diana Ferman, Carlota Conant, Katherin Martin, Kristin Oleary, Sonia Pawluczyk, Elizabeth Trejo, Karen Dagerman, Liberty Teodoro, Mauricio Becerra, Madiha Fairooz, Sonia Garrison, Julia Boudreau, Yair Avila, James B. Brewer, Aaron Jacobson, Antonio Gama, Chi Hun Kim, Emily Little, Jennifer C. Frascino, Nichol Ferng, Socorro Trujillo, Judith L. Heidebrink, Steven MacDonald, Dariya Malyarenko, James P.B. O’Connor, Nicole Robert, Suzan Lowe, Virginia Rogers, Barbara Hackenmiller, Bradley F. Boeve, Colleen S. Albers, Connie Kreuger, David T. Jones, David S. Knopman, Hugo Botha, Jessica Magnuson, Jonathan Graff‐Radford, Kerry CrawleyW, Michaël Schumacher, Sanna McKinzie, Steven Smith, Tascha Helland, Val J. Lowe, Vijay K. Ramanan, Valory Pavlik, Jacob Faircloth, Jeffrey Bishop, Maria ChaudharyP, Maria Kataki, Melissa Yu, Nathiel Pacini, Randall Barker, Regan Brooks, Ruchi Aggarwal, Lawrence S. Honig, Yaakov Stern, Akiva Mintz, Jonathan Cordona, Michelle L. Hernandez, Justin Alexander Long, Abbey Arnold, Alex Groves, Anna Middleton, Blake Vogler, Cierra McCurry, Connie Mayo, Cyrus A. Raji, Fatima Amtashar, Heather KlempW, Heather Nicole Elmore, Jasmina Kusuran, Jasmine Stewart, Jennifer Horenkamp, Julia Greeson, Kara Wever, K.-P. Vo, Kelly Larkin, Lisa Schoolcraft, Lora Gallagher, Madeline Paczynski, M. G. McMillan, Michael Holt, Nicole Gagliano, Rachel L. Henson, Renee LaBarge, Robert A. Swarm, Sarah MunieN, Serena Cepeda, Stacey WintertonN, Stephen Hegedus, TaNisha Wilson, Tanya Harte, Zach Bonacorsi, David Geldmacher, Amber Watkins, Brandi BargerRT, Bryan Smelser, Charna Bates, Cynthia Stover, Emily McKinley, Gregory Ikner, Haley Hendrix, Harold Matthew Cooper, J. A. Mahaffey, Lindsey Booth Robbins, Loren Brown Ashley, Marissa Natelson-Love, Princess Carter, Veronika Solomon, Hillel Grossman, Alexandra Groome, Allison Ardolino, Anthony Kaplan, Faye Sheppard, Genesis Burgos-Rivera, Gina Garcia-Camilo, Joanne Mun-Yee Lim, Judith Neugroschl, Kimberly Jackson, Kirsten Evans, Laili Soleimani, Mary Sano, Nasrin Ghesani, Sarah Binder, Xiomara Mendoza Apuango, Amelia Troutman, Kimberly S. Blanchard, Arlene Richards, Grace Nelson, Kirsten HendricksonN, Erin Yurko, J. Plenge, Victoria Rufo, Raj J. Shah, Ranjan Duara, Brendan Lynch, Cesar Chirinos, Christine Dittrich, Debbie Campbell, Diego Mejia, Gilberto Perez, Helena Colvee, Joanna Gonzalez, Josalen Gondrez, J Knaack, Mara Acevedo, Maria Cereijo, Maria T. Greig‐Custo, Michelle Villar, Morris Wishnia, Sheryl Detling, Warren Barker, Marilyn Albert, Abhay Moghekar, Barbara Rodzon, Corey Demsky, Gregory M. Pontone, Leonie Farrington, Martin G. Pomper, Nicole L. Johnson, Tolulope Alo, Martin Sadowski, Anaztasia Ulysse, Arjun V. Masurkar, B Marti, David Mossa, Emilie Geesey, Emily Petrocca, Evan T. Schulze, Jennifer Wong, Joseph Boonsiri, Sunnie Kenowsky, Tatianne Martinez, Veronica Briglall, Priyanka Murali, Adaora Nwosu, Alisa Adhikari, Cammie Hellegers, Jeffrey R. Petrella, Olga James, Terence Z. Wong, Thomas C. Hawk, Sanjeev Vaishnavi, Hannah McCoubrey, Ilya M. Nasrallah, Rachel Rovere, Jeffrey Maneval, Elizabeth J. Robinson, Francisco Rivera, Jade Uffelman, Martha A. Combs, Patricia O’Donnell, Sara L. Manning, Richard King, Alayne NietoN, Amanda C. Glueck, Anjana Mandal, Audrie Swain, Bethanie Gamble, Martha Meacham, Denece Forenback, Dorothy Ross, Elizabeth Cheatham, Ellen Hartman, Gary Cornell, Jordan P. Harp, Laura Ashe, Laura Goins, Linda Watts, Morgan Yazell, Prabin Mandal, Regan BucklerN, S.R. Vincent, Triana Rudd, Oscar L. Lopez, Ann Malia Arlene, Caitlin Chiado, Cary Zik, K. E. Savage, Linda Fenice, MaryAnn Oakley, Paige C Tacey, Sarah R. Berman, Sarah Bowser, Xanthia Saganis, Anton P. Porsteinsson, Abigail Mathewson, Asa Widman, Bridget Holvey, Emily Clark, Esmeralda Morales, CA Young, Kevin Hopkins, Kimberly Martin, Nancy Kowalski, Rebecca Hunt, Roberta Calzavara, Russell Kurvach, Conchita D’Ambrosio, Gaby Thai, Beatriz Vides, Brigit Lieb, Catherine Mc-Adams-Ortiz, Cyndy Toso, Ivan Mares, Kathryn Moorlach, Luter Liu, Maria Corona, Mary Nguyen, Melanie Tallakson, Michelle N. McDonnell, Milagros Rangel, Neetha Basheer, Patricia Place, Romina A. Romero, Steven Tam, Trung Nguyen, Abey Thomas, Alexander O. Frolov, Alka Khera, Amy Browning, Robert C. Dawson, Dana Mathews, Elaine Most, Elizeva Phillips, Lynn Nguyen, Maribel Nunez, Matalin Miller, Richard A. Matthew, Natalie Martinez, Caroline Logan, Roderick McColl, Sari Pham, Tiffani Fox, Tracey Moore, Allan I. Levey, Abby Brown, Andrea Kippels, Ashton Ellison, Casie Lyons, Chadwick M. Hales, Cindy Parry, Courtney L. Williams, Elizabeth McCorkle, Guy Harris, Heather Rose, Inara Jooma, Jahmila Al-Amin, James J. Lah, J. Webster, Jessica Swiniarski, Laura Donnelly, Lauren Mariotti, Mary Locke, Phyllis Vaughn, Rachael Penn, Sallie Carpentier, Samira Yeboah, Sarah Basadre, Sarah Malakauskas, Stefka Lyron, Tara Villinger, Terra Burney, Jeffrey M. Burns, C Ala Abusalim, Alexandra Dahlgren, Alexandria Montero, Anne Arthur, Heather Dooly, Katelynn Kreszyn, Katherine Berner, Lindsey Gillen, Maria Scanlan, Mercedes Madison, Nicole Mathis, Phyllis Switzer, Ryan Townley, Samantha Fikru, Samantha Sullivan, Ella Wright, Maryam Beigi, Anthony Daley, Ashley Ko, Brittney Luong, Glen Nyborg, Jessica Morales, Kelly A. Durbin, Lauren Garcia, Leila Parand, Lorena Macias, Lorena Monserratt, Maya Farchi, Pauline Wu, Robert Hernandez, Thao Rodriguez, Neill R. Graff‐Radford, A’llana Marolt, Anton Thomas, Deborah Aloszka, Ercilia Moncayo, Erin Westerhold, Gregory Day, Kandise Chrestensen, Mary Imhansiemhonehi, Sochenda Stephens, Sylvia Grant, Jared R. Brosch, Amy Perkins, Aubree Saunders, Debra Silberberg Kovac, Heather Polson, Isabell Mwaura, Kassandra Mejia, Katherine Britt, Kathy King, Kayla Nichols, Kayley Lawrence, Lisa Rankin, Martin R. Farlow, Patricia Wiesenauer, Robert W. Bryant, Scott Herring, Sheryl Lynch, Skylar Wilson, Traci Day, William Korst, Christopher van Dyck, Adam P. Mecca, Alyssa Miller, Amanda Brennan, Amber Khan, Audrey Ruan, Carol Gunnoud, Chelsea Mendonca, Danielle Raynes-Goldfinger, Elaheh Salardini, Elisa Hidalgo, Emma Cooper, E.A. Singh, Erin Murphy, Jeanine May, Jesse Stanhope, Jessica Lam, Julia Waszak, Kimberly Nelsen, Kimberly Sacaza, Mayer Joshua Hasbani, Meghan Donahue, Ming-Kai Chen, Nicole Barcelos, Paul Eigenberger, Robin Bonomi, Ryan S. O’Dell, Sarah Jefferson, Siddharth Khasnavis, Stephen Smilowitz, Susan DeStefano, Susan P. Good, Terry Camarro, Vanessa Clayton, Yanis Cavrel, YuQuan “Oliver” Lu, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra E. Black, Anish Kapadia, Aparna Bhan, Benjamin Lam, Gillian Gabriel, Jennifer Bray, Ljubica Zotovic, Maria Samira Gutierrez, Mario Masellis, Marjan Farshadi, Maurylette Gui, Meghan Mitchellc, Rebecca L. Taylor, Ruby Endre, Zhala Taghi-Zada, Carolyn English, Ellen Kim, Eugene Yau, Haley Tong, Laura Barlow, Lauren Jennings, Michele Assaly, Paula Nunes, Tahlee Marian, Andrew Kertesz, John Rogers, Dick Trost, Dylan Wint, Charles Bernick, Donna Munic, Ian Grant, Aaliyah Korkoyah, Ali S. Raja, Allison Lapins, Caila Ryan, Jelena Pejić, Kailey Basham, Leena Lukose, Loreece Haddad, Lucas Quinlan, Nathaniel Houghtaling, Carl Sadowsky, Walter Martínez, Teresa Villena, Brigid Reynolds, Angelica Forero, Carolyn Ward, Emma Brennan, Esteban Figueroa, Giuseppe Esposito, Jessica Mallory, Kathleen Johnson, Kathryn Turner, Katie Seidenberg, Kelly McCann, Margaret Bassett, Melanie Chadwick, Raymond Scott Turner, Robin Bean, Saurabh Sharma, Gad A. Marshall, Aferdita Haviari, Christophe Pietras, Bradley Wallace, Catherine E. Munro, Gladiliz Rivera-Delpin, Hadley Hustead, Isabella Levesque, Jennifer Ramirez, Marie T. Nolan, Kirsten Glennon, Mariana Palou, Michael Erkkinen, Nicole DaSilva, Pamela Friedman, Regina M Silver, Ricardo Salazar, Roxxanne Polleys, Scott McGinnis, Seth A. Gale, Tia C. Hall, Lưu Trọng Tuấn, Steven Chao, Emmeline Lin, Jaila Coleman, Kevin Epperson, Minal Vasanawala, Alireza Atri, Amy Rangel, Brittani Evans, Candy Monarrez, Carol Cline, Carolyn Liebsack, Daniel Bandy, Danielle Goldfarb, Debbie Intorcia, Jennifer Olgin, Kelly Clark, Kelsey King, Kylee York, Marina Reade, Michael Callan, Michael Glass, Michaela Johnson, Michele Gutierrez, Molly Goddard, Nadira Trncic, Parichita Choudhury, P. V. Reyes, Serena Lowery, Shaundra Hall, Sonia Olgin, Stephanie Santiago, Michael L. Alosco, Alyssa Ton, Amanda Jiménez, Andrew Ellison, Anh T. Tran, Brandon Anderson, Della Carter, Donna Veronelli, Eric Steinberg, Jason Weller, Jennifer Johns, Jessica Harkins, Ina Hoti, Jane Mwicigi, Olivia Schultz, Mona Lauture, Ridiane Denis, Ronald Killiany, Sarab Singh, Wendy Qiu, Ycar Devis, Thomas O. Obisesan, Andrew Stone, Debra Ordor, Ifreke Udodong, Immaculata Okonkwo, Javed Khan, Jillian Turner, Kyliah Hughes, Oshoze Kadiri, Charles Duffy, Ariana Moss, Katherine Stapleton, Mária Tóth, Marianne Sanders, Martin Ayres, Melissa Hamski, Parianne Fatica, Paula Ogrocki, Sarah Ash, Stacy Pot, Doris Chen, Andrés Soto, Costin Tanase, David Bissig, Hafsanoor Vanya, Heather Russell, Hitesh Patel, Hongzheng Zhang, Kelly Wallace, Kristi Ayers, Maria Gallegos, Martha R. Forloines, M. Sinn, Queennie Majorie S Kahulugan, Richard Isip, Sandra Calderon, Talia Hamm, Michael Borrie, T‐Y Lee, Robert Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Allison Perrin, Pierre N. Tariot, Adam J. Fleisher, Stephanie Reeder, Horacio Capote, Allison Emborsky, Anna G. Mattle, Bela Ajtai, Christina Wagner, Bennett Myers, Daryn Slazyk, C Delaney Fragale, Erin Fransen, Heather Macnamara, C Jonathan Falletta, Joseph Hirtreiter, Laszlo Mechtler, Megan E. King, Michael Asbach, Michelle Rainka, R Zawislak, Scott Wisniewski, Claire O’Malley, Tatiana Jimenez-Knight, Todd Peehler, Traci Aladeen, Vernice Bates, Violet Wenner, Wisam Elmalik, Douglas W. Scharre, Arun Ramamurthy, Soumya Bouchachi, Rawan Tarawneh, Dzintra Celmins, Alicia Leader, Chris Figueroa, Heather Bauerle, Katlynn Patterson, Michael Reposa, Steven Presto, Tuba Ahmed, Wendy Stewart, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Robert B. Santulli, Eben S. Schwartz, Jeff Williamson, Alicia Jessup, A. Williams, Crystal Duncan, Abigail O’Connell, Karen Gagnon, Ezequiel Zamora, James Bateman, Freda Crawford, Deb Thompson, E. R. C. Walker, Jennifer Rowell, Mikell White, Phillip Hunter Ledford, Sarah Bohlman, Susan Henkle, Joseph Bottoms, Lena Moretz, Bevan Hoover, Michael Shannon, Christiane Rogers, Wendy Baker, William Harrison, Chuang‐Kuo Wu, Alexis DeMarco, Ava Stipanovich, Daniel Arcuri, Jan Clark, Jennifer Davis, Kerstin Doyon, Marie Amoyaw, Mauro Veras Acosta, Ronald Bailey, Scott Warren, Terry Fogerty, Victoria Sanborn, Meghan Riddle, Stephen Salloway, Paul Malloy, Stephen Correia, Charles Windon, Morgan Blackburn, Howard J. Rosen, Bruce L. Miller, Amanda Smith, Ijeoma Mba, Jenny Echevarria, Emily Roglaski, Meagan Yong, Rebecca Devine, Hamid Okhravi, Edgardo Rivera, Teresa Kalowsky, Caroline Smith, Christina Rosario, Joseph C. Masdeu, Richard H. Le, Maushami Gurung, Marwan Sabbagh, Angelica Garcia, Micah Ellis Slaughter, Nadeen Elayan, Skieff Acothley, Nunzio Pomara, Raymundo Hernando, Vita Pomara, Olga Brawman‐Mintzer, Allison Acree, Arthur Williams, Campbell Long, Rebecca Long, Paul Newhouse, Sydni Jenee Hill, Amy Boegel, Sudha Seshadri, Amy R. Saklad, Floyd Jones, William Hu, V Sotelo, Yaneicy Gonazalez Rojas, Jacobo Mintzer, Crystal Flynn Longmire, Kenneth Spicer, Frederik Barkhof, Thomas Benke, Christopher Chen, Peter Dal‐Bianco, Anna Dewenter, Marco Duering, Christian Enzinger, Michael Ewers, Lieza G. Exalto, Nicolai Franzmeier, Saima Hilal, Edith Hofer, Huiberdina L. Koek, Andrea B. Maier, Pauline Maillard, Cheryl R. McCreary, Janne M. Papma, Yolande A.L. Pijnenburg, Reinhold Schmidt, Eric E. Smith, Rebecca M. E. Steketee, Esther van den Berg, Wiesje M. van der Flier, Vikram Venkatraghavan, Narayanaswamy Venketasubramanian, Meike W. Vernooij, Frank J. Wolters, Xin Xu, Andreas Horn, Kaustubh R. Patil, Simon B. Eickhoff, Götz Thomalla, J. Matthijs Biesbroek, Geert Jan Biessels, Bastian Cheng
Bibliographic record
VenueBrain · 2024
Typearticle
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsUniversity of Calgary
FundersNational Institute of Biomedical Imaging and BioengineeringCanadian Institutes of Health ResearchNational Institutes of HealthGenentechIXICOH. Lundbeck A/SEisaiZonMwDeutsche ForschungsgemeinschaftServierEU Joint Programme – Neurodegenerative Disease ResearchNorthern California Institute for Research and EducationDoD Alzheimer's Disease Neuroimaging InitiativeBioClinicaBiogenPfizerNovartis Pharmaceuticals CorporationUniversity of Southern CaliforniaU.S. Department of DefenseEli Lilly and CompanyBristol-Myers SquibbAlzheimer's Disease Neuroimaging InitiativeMeso Scale DiagnosticsNational Institute on AgingAlzheimer's Association
KeywordsCognitionHyperintensityEffects of sleep deprivation on cognitive performanceWhite matterPsychologyConnectomeCognitive testMedicineMagnetic resonance imagingNeuroscienceFunctional connectivityRadiology
Abstract
White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating brain health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH to these deficits remain unclear. Lesion network mapping (LNM) enables us to infer if brain networks are connected to lesions and could be a promising technique for enhancing our understanding of the role of WMH in cognitive disorders. Our study employed LNM to test the following hypotheses: (i) LNM-informed markers surpass WMH volumes in predicting cognitive performance; and (ii) WMH contributing to cognitive impairment map to specific brain networks. We analysed cross-sectional data of 3485 patients from 10 memory clinic cohorts within the Meta VCI Map Consortium, using harmonized test results in four cognitive domains and WMH segmentations. WMH segmentations were registered to a standard space and mapped onto existing normative structural and functional brain connectome data. We employed LNM to quantify WMH connectivity to 480 atlas-based grey and white matter regions of interest (ROI), resulting in ROI-level structural and functional LNM scores. We compared the capacity of total and regional WMH volumes and LNM scores in predicting cognitive function using ridge regression models in a nested cross-validation. LNM scores predicted performance in three cognitive domains (attention/executive function, information processing speed, and verbal memory) significantly better than WMH volumes. LNM scores did not improve prediction for language functions. ROI-level analysis revealed that higher LNM scores, representing greater connectivity to WMH, in grey and white matter regions of the dorsal and ventral attention networks were associated with lower cognitive performance. Measures of WMH-related brain network connectivity significantly improve the prediction of current cognitive performance in memory clinic patients compared to WMH volume as a traditional imaging marker of cerebrovascular disease. This highlights the crucial role of network integrity, particularly in attention-related brain regions, improving our understanding of vascular contributions to cognitive impairment. Moving forward, refining WMH information with connectivity data could contribute to patient-tailored therapeutic interventions and facilitate the identification of subgroups at risk of cognitive disorders.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.443
Threshold uncertainty score0.749
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.020
GPT teacher head0.267
Teacher spread0.247 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations17
Published2024
Admission routes2
Has abstractyes