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Record W4403410406 · doi:10.1016/j.jtho.2024.09.026

OA02.03 Amivantamab Plus Lazertinib vs Osimertinib in First-line EGFR-mutant Advanced NSCLC: Longer Follow-up of the MARIPOSA Study

2024· article· en· W4403410406 on OpenAlexfundno aff
S. Gadgeel, B.C. Cho, S. Lu, E. Felip, Hidetoshi Hayashi, A.I. Spira, B. Besse, Michael Thomas, Scott Owen, Yoon Jun Kim, S.-H. Lee, Josiane Mourão Dias, Y.-G. Lee, Yong Zhao, Yun Fang, N. Girard, Zhen Liu, Ping Sun, Sabrina Oliveira, Hong Shen, L. Paz-Ares, Shingo Matsumoto, Haruo Tanaka, A.R. Ahmad, Т. Андабеков, P. Sunpaweravong, Özgür Özyılkan, J.C.-H. Yang, Maya Gottfried, Olga Susana Suárez Hernández, M. Kimmich, D. Cortinovis, D.L. Kaen, Lizbett Vanessa Garcia Montes, Sanjay Popat, Tom Newsom‐Davis, Juanjuan Xie, Tao Sun, E. Fennema, Mahesh Daksh, Marguerite Ennis, Seema Sethi, Joshua Bauml, Dinh Chuong Nguyen

Bibliographic record

VenueJournal of Thoracic Oncology · 2024
Typearticle
Languageen
FieldMedicine
TopicLung Cancer Treatments and Mutations
Canadian institutionsnot available
FundersSamsungUniversité de Versailles Saint-Quentin-en-YvelinesSir Run Run Shaw HospitalFaculty of Medicine, Prince of Songkla UniversityDeutsches Zentrum für LungenforschungCollege of Medicine, Seoul National UniversitySeoul National University Bundang HospitalPrince of Songkla UniversityInstitut Gustave-RoussyYonsei University College of MedicineMcGill UniversityBaskent ÜniversitesiShanghai Jiao Tong UniversityRoyal Marsden NHS Foundation TrustKindai UniversityZhejiang UniversitySungkyunkwan UniversityYonsei UniversityDeutsches KrebsforschungszentrumCapital Medical UniversitySeoul National UniversityZhengzhou UniversityCity of HopeKanazawa UniversityNationales Centrum für Tumorerkrankungen HeidelbergUniversitätsklinikum HeidelbergHospital de Câncer de BarretosShanghai Chest Hospital
KeywordsOsimertinibMedicineOncologyMutantFirst lineSecond lineInternal medicineLine (geometry)Epidermal growth factor receptorGeneticsCancerBiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0030.006
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.425
Teacher spread0.403 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2024
Admission routes1
Has abstractno

Explore more

Same venueJournal of Thoracic OncologySame topicLung Cancer Treatments and MutationsFrench-language works237,207