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Record W4403537808 · doi:10.1016/j.esmoop.2024.103837

97P Population-based assessment of outcomes in pancreatic ductal adenocarcinoma (PDAC) patients (pts) with pathogenic germline variants (PGVs)

2024· article· en· W4403537808 on OpenAlexaffabout
Phoebe T. M. Cheng, Kasmintan A. Schrader, Catherine Cremin, Eugene Cheung, Ana Fisic, James T. Topham, Joanna M. Karasinska, Benjamin J.W. Chow, David J. Schaeffer, Daniel J. Renouf

Bibliographic record

VenueESMO Open · 2024
Typearticle
Languageen
FieldMedicine
TopicPancreatic and Hepatic Oncology Research
Canadian institutionsVancouver General HospitalUniversity of British ColumbiaUniversity of British Columbia HospitalBC Cancer Agency
Fundersnot available
KeywordsPancreatic ductal adenocarcinomaGermlineOncologyInternal medicineMedicinePopulationPancreatic cancerCancer researchBiologyCancerGeneticsGeneEnvironmental health

Abstract

fetched live from OpenAlex

Outcomes in PDAC have historically been poor with median overall survival (mOS) less than 12 months (mo) in advanced cases, though may be better in pts with PGVs in cancer susceptibility genes, particularly those involved in DNA repair with actionable mutations. We evaluated clinical features and survival of PDAC pts with PGVs detected using a universal germline testing approach in the population-based cancer system in British Columbia, Canada.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.502
Threshold uncertainty score0.998

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.002
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.375
Teacher spread0.345 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes2
Has abstractyes

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