Developmental changes in the control of primary motoneuron excitability by the M-current in larval zebrafish
Bibliographic record
Abstract
ABSTRACT Spinal circuits for locomotion undergo maturation during early development. How intrinsic properties of individual spinal neuron populations change throughout motor maturation is not fully understood. Here we identify for the first time the presence of the persistent outward potassium current known as the M-current in primary motoneurons of larval zebrafish. We show that the M-current controls excitability of primary motoneurons and its role in excitability control changes during development such that the magnitude of the M-current in primary motoneurons transiently increases at 3 days post-fertilization. These findings reveal a novel mechanism by which control over excitability of primary motoneurons in larval zebrafish is ensured, underscoring developmental changes in ion current contributions to intrinsic properties. Broadly, these data support the M-current as a conserved means to control motoneuron excitability across vertebrates.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".