Eight-week glecaprevir/pibrentasvir in Canadian hepatitis C virus-infected, treatment-naïve, compensated cirrhotic people: CREST study
Bibliographic record
Abstract
Aim: Evaluation of the real-world effectiveness and safety of 8-week glecaprevir/pibrentasvir (G/P) in treatment-naive Canadian individuals with hepatitis C and compensated cirrhosis.Patients & methods: Analysis of Canadian people enrolled in the CREST study. Primary end point was sustained virologic response at posttreatment Week 12 (SVR12) rates; safety end points were also assessed.Results: Fifty-three individuals received ≥1 dose of G/P. In the modified analysis set (MAS; which excluded those who discontinued G/P [n = 1] or with missing SVR12 data [n = 12]), 98% (39/40) achieved SVR12; 1 person experienced virologic failure. No individuals experienced or discontinued treatment due to a serious adverse event.Conclusion: In this real-world Canadian cohort, 8-week G/P was well tolerated, with SVR12 rates similar to those in clinical trials.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".