Study of immune response in a latent tuberculosis infection model
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
A simple mathematical model describing the immune response during the stage latent tuberculosis infection is established and analyzed. The main purpose of this study is to explore the sustained immune response of the immune system against invaded Mycobacterium tuberculosis in the stage of latent tuberculosis infection. First, the threshold R 0 is defined to determine the occurrence of sustained immune response. Then, stability conditions are derived to show that the sustained immune response may converge to a constant or to a stable periodical oscillation, implying that the Mycobacterium tuberculosis , the infected macrophages, the activated uninfected macrophages, and the immune cells coexist to form the tuberculous granuloma structure. This structure may appear calcified if the system solution converges to a constant, or maintains a dynamic balance if the system solution undergoes a periodical oscillation. These findings well demonstrate the process of sustained immune response in the latent tuberculosis infection as the Mycobacterium tuberculosis is changing. Numerical examples are presented to illustrate the theoretical predictions.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it