Genomic profiles and outcomes in de novo versus therapy-related core binding factor AML
Bibliographic record
Abstract
Core binding factor acute myeloid leukemia (CBF-AML), characterized by the recurrent translocations of t(8;21)(q22;q22) or inv(16)(p13.1q22)/t(16;16)(p13.1;q22), hereafter abbreviated as t(8;21) and inv(16), is associated with favorable outcome and response well to high-dose cytarabine-based therapy [ 1 , 2 ]. Approximately 15% of CBF-AML cases are therapy-related, typically arising after topoisomerase II inhibitor exposure. While the outcomes of therapy-related acute promyelocytic leukemia are comparable to de novo cases, therapy-related CBF-AML (t-CBF-AML) has variably reported inferior outcomes compared to de novo CBF-AML (dn-CBF-AML) [ 3 , 4 , 5 , 6 ], often influenced by factors such as older age, antecedent malignancies, and cumulative treatment toxicity [ 7 ]. The ELN 2022 defined myelodysplasia-related cytogenetics (MDS-cyto) and myelodysplasia-related gene (MDS-gene) mutations are commonly found in t-AML and are associated with adverse prognosis [ 7 , 8 ], but their significance in t-CBF-AML is unclear. Secondary cytogenetic abnormalities (SCA) and gene mutations are also frequent in CBF-AML, though their prognostic significance remains controversial [ 3 , 4 , 9 , 10 , 11 ].
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.007 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".