Fused-fiber-photometry based on a low-autofluorescence wideband multimode circulator
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Analysis of fluorescent signals in biological samples is widely used in the fields of life science and medicine and can be achieved through conceptually distinct approaches. Here, we report the use of a wideband multimode circulator (WMC), a three-port optical fused-fiber device with an asymmetrical structure specifically designed to ensure efficient light transmission in both illumination and collection paths. It features a flat spectral response and is ideally suited for simultaneous excitation and detection of fluorescence in biological tissue. The WMC used in this work was further improved by minimizing its inherent background autofluorescence. Using the WMC, we demonstrate improved fluorescence detection against already existing fiber-based approaches. Finally, we utilize the WMC to establish fiber photometry recordings in vivo to infer neuronal activity in a small neuromodulatory nucleus in the brainstem of an awake mouse.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it