Idiothetic representations are modulated by availability of sensory inputs and task demands in the hippocampal-septal circuit
Bibliographic record
Abstract
The hippocampus is a higher-order brain structure responsible for encoding new episodic memories and predicting future outcomes. In the absence of external stimuli, neurons in the hippocampus track elapsed time, distance traveled, and other idiothetic variables. To this day, the exact determinants of idiothetic representations during free navigation remain unclear. Here, we developed unsupervised approaches to extract population and single-cell properties of more than 30,000 CA1 pyramidal neurons in freely moving mice. We find that spatiotemporal representations are composed of a mixture of idiothetic and allocentric information, the balance of which is dictated by task demand and environmental conditions. Additionally, a subset of CA1 pyramidal neurons encodes the spatiotemporal distance to rewards. Finally, distance and time information is integrated postsynaptically in the lateral septum, indicating that these high-level representations are effectively integrated in downstream neurons.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".