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Record W4404259354 · doi:10.1016/j.xpro.2024.103420

Protocol for Xenium spatial transcriptomics studies using fixed frozen mouse brain sections

2024· article· en· W4404259354 on OpenAlexfundno aff
Xiaokuang Ma, Peng Chen, Wei Jing, Yingsheng Zhang, Chang-Er Chen, Hanqiu Zhao, Deveroux Ferguson, Aaron W. McGee, Zhiyu Dai, Shenfeng Qiu

Bibliographic record

VenueSTAR Protocols · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicSingle-cell and spatial transcriptomics
Canadian institutionsnot available
FundersNational Eye InstituteNational Institute of Mental HealthNational Institute on AgingNational Institutes of HealthNational Heart, Lung, and Blood InstituteUniversity of ArizonaArizona Biomedical Research CommissionInstitut de recherche en santé mentale
KeywordsProtocol (science)Computer scienceComputational biologyBiologyMedicinePathology

Abstract

fetched live from OpenAlex

.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Protocol · Consensus signal: none
Teacher disagreement score0.072
Threshold uncertainty score0.242

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0030.003
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0040.002
Science and technology studies0.0040.001
Scholarly communication0.0010.001
Open science0.0040.001
Research integrity0.0020.006
Insufficient payload (model declined to judge)0.0720.039

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.126
GPT teacher head0.415
Teacher spread0.289 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreProtocol

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations16
Published2024
Admission routes1
Has abstractyes

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