PEG 400-Catalyzed C3 & O-Alkylation Reactions of 4-Hydroxycoumarin-A Study
Why this work is in the frame
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Bibliographic record
Abstract
PEG-400 has been found to be an efficient recyclable catalyst/solvent system for C3- and O-alkylation of 4-hydroxycoumarin with various electronically and structurally divergent alcohols with moderate to good yield of products. For the C3-alkylation using styrenes required Zn(OAc)2.2H2O (5 mol%) in PEG-400 at 70 °C. For the O-alkylation of 4-hydroxycoumarin with acetates required PEG-400 at 60 °C. This process offered a gentle and uncomplicated way to obtain multi-substituted pyranocoumarins, as well. This protocol's benefits include its wide use, moderate environment, low cost, reusable catalyst (PEG-400), and ease of usage due to the only byproducts being acetic acid and water, respectively.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it