Bitter taste genetics and oral health in Canadian Longitudinal Study on Aging
Bibliographic record
Abstract
SUMMARY This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) in 25 Bitter Taste Receptor genes ( TAS2R s) and 12 TAS2R pseudogenes with self-reported oral health outcomes in the Canadian Longitudinal Study on Aging (CLSA) cohort. Following quality control, 124 SNPs with a minor allele frequency > 0.01 and 21,991 individuals of European ancestry were included in the analysis. Fifteen SNPs in TAS2R8, 9, 13, 14, 20 , and 50 were significantly associated with self-reported sore jaw muscles, a symptom commonly linked to temporomandibular disorders (TMDs). TAS2R20 exhibited the highest number of associated SNPs. Structure-function analysis suggests that variants in TAS2R20 may contribute to this symptom by altering ligand interactions. These findings highlight the potential for TAS2R genetic screening to identify individuals at elevated risk for TMD, supporting the development of personalized treatment strategies and advancing our understanding of TMD genetic risk factors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".