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Record W4404824388 · doi:10.1038/s41551-024-01259-7

Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses

2024· article· en· W4404824388 on OpenAlexafffund
Reza Rezaei, Stephen Boulton, Mahsa Ahmadi, Julia Petryk, Miles Da Silva, Nika Kooshki Zamani, Ragunath Singaravelu, Gabriel St-Laurent, Lauren Daniel, Arezoo Sadeghipour, Adrian Pelin, Joanna Poutou, Abril Ixchel Muñoz Zúñiga, Victoria H. Gilchrist, Zumama Khalid, Bradley Austin, Kemal Alper Onsu, Ricardo Marius, Zahra Ameli, Fazel Mohammadi, Valeria Mancinelli, Emily A. Wang, Abolfazl Nik-Akhtar, Akram Alwithenani, Fatemeh Panahi Arasi, Stephen S. G. Ferguson, Tom C. Hobman, Tommy Alain, Lee‐Hwa Tai, Carolina S. Ilkow, Jean‐Simon Diallo, John C. Bell, Taha Azad

Bibliographic record

VenueNature Biomedical Engineering · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicVirus-based gene therapy research
Canadian institutionsUniversity of AlbertaChildren's Hospital of Eastern OntarioCarleton UniversityCentre Hospitalier Universitaire de SherbrookeUniversité de SherbrookeUniversity of British ColumbiaOttawa HospitalUniversity of Ottawa
FundersCIHR Skin Research Training CentreGovernment of Canada
KeywordsOncolytic virusBiologyInsertional mutagenesisVirologyMutagenesisVirusGenomeGeneViral replicationVacciniaTransgeneRecombinant virusComputational biologyMutationGeneticsRecombinant DNA

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.281
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2024
Admission routes2
Has abstractno

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