Tratamentul sialoreei induse de clozapină la pacienţii cu schizofrenie – studiu-pilot cu o suspensie extemporanee oromucozală de trospiu
Bibliographic record
Abstract
Introdution. Clozapine is a life-saving drug in treatment-resistant schizophrenia (TRS). Clozapine-induced sialorrhea (CIS) is a common adverse effect that frequently leads to reduced treatment adherence and additional complications, thus affecting its efficacy in treatment-resistant schizophrenia. Objective. The aim of this article was to report two cases of CIS in two TRS patients who were treated using an extemporaneously compounded trospium oromucosal suspension. Methodology. The severity and frequency of CIS were evaluated using two different scales, the Toronto Nocturnal Hypersalivation Rating Scale (TNHR) and the Drooling Severity and Frequency Scale (DSF), before and during trospium treatment. Conclusions. We considered this trospium-based extemporaneously compounded oromucosal formulation as a promising solution for CIS and for maintaining clozapine adherence in patients with treatment-resistant schizophrenia.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".