Decavanadates and polyanion-polycation interactions: from minerals to proteins
Why this work is in the frame
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Bibliographic record
Abstract
The decavanadate polyanions [V 10 O 28 ] 6– , [H x V 10 O 28 ] (6–x)– and [(M 4+ x V 5+ 10–x )O 28 ] (6+x)– are constituents of the pascoite-family minerals. The interaction between the interstitial complex and the decavanadate structural unit may be analyzed using the principle of correspondence of Lewis acidity-basicity. The Lewis base strengths of the decavanadate polyanions vary from 0.054 to 0.135 vu and [V 10 O 28 ] structures can form from Cs + , Rb + , K + , Tl + and Na + ; simple cations with higher Lewis acidities are too acidic to form structures. Such cations bond to transformer (H 2 O) groups to form polyatomic cations that have lower Lewis acidities than the corresponding simple cations. In the pascoite-family minerals, the stereochemical details of the decavanadate ion are modified by (1) exploiting the two different patterns of bond-length arrangement in [6] V 5+ , (2) substituting tetravalent cations for V 5+ at one of the octahedra, and (3) protonating the decavanadate ion. These mechanisms change the individual Lewis basicities of the 26 external O 2– ions of the polyanion, allowing great versatility in the binding of decavanadate ions to constituent polycations of crystallizing structures. This suggests that the [V 10 O 28 ] polyanions may be used to induce co-crystallization of large aqueous polyatomic cations, facilitating their structural characterization. Decavanadate can also induce crystallization of proteins and is of major importance in protein crystallography because of this capability. Proteins and enzymes can bind to the decavanadate ion as very large polyatomic cations, modifying their function and showing potential for treating various forms of cancer, Alzheimer’s disease, AIDS, diabetes and COVID-19.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it