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Record W4405081578 · doi:10.1161/atvbaha.124.321108

On-Treatment Change in <scp>d</scp> -Dimer Is Associated With Differential Outcomes Among Therapeutic Dose Heparin-Treated Noncritically Ill Patients Hospitalized for COVID-19

2024· letter· en· W4405081578 on OpenAlexafffund
Lana Wahid, Joshua Froess, Thomas L. Ortel, Ryan Zarychanski, Jeffrey S. Berger, Mary Cushman, Derek C. Angus, Valerie J. Renard, Parisa Farahani, Steve Webb, Anna Heath, Lucas C. Godoy, Michael E. Farkouh, Judith S. Hochman, Matthew D. Neal, Patrick R. Lawler

Bibliographic record

VenueArteriosclerosis Thrombosis and Vascular Biology · 2024
Typeletter
Languageen
FieldMedicine
TopicCOVID-19 Clinical Research Studies
Canadian institutionsMcGill University Health CentreInstitute of Health Services and Policy ResearchInstitute for Clinical Evaluative SciencesHospital for Sick ChildrenPublic Health OntarioUniversity of TorontoCancerCare Manitoba
FundersNational Heart, Lung, and Blood InstituteCanadian Institutes of Health ResearchDefense Advanced Research Projects AgencyCenters for Disease Control and PreventionNational Institutes of HealthCancerCare Manitoba FoundationLifeArcUniversity of PittsburghResearch ManitobaBrigham and Women's HospitalNatural Sciences and Engineering Research Council of CanadaSanofi
KeywordsHeparinMedicineCoronavirus disease 2019 (COVID-19)D-dimerPharmacologyIntensive care medicineInternal medicineDisease

Abstract

fetched live from OpenAlex

This study is reporting on a clinical randomized control trial: Yes Clinical trial reports should comply with the Consolidated Standards of Reporting Trials ( CONSORT) including its additional extensions as appropriate.This should include a flow diagram presenting the screening, enrollment, intervention allocation, follow-up, and data analysis with number of subjects for each.Please refer specifically to the CONSORT Checklist of items to include when reporting a randomized clinical trial and provide the completed checklist at the time of submission.Please confirm and provide the following details at this time: Clinical Trial RegistrationClinical trials should be registered in an appropriate online trial registry at or before the onset of participant enrollment.In the box below, please provide the name of the trial registry, the registry URL, and the trial registration number.If your study is a clinical trial but not registered, please provide an explanation below.https://classic.clinicaltrials.gov/ct2/show/NCT04505774 Sex and Race/Ethnicity Specific ResultsSex and race/ethnicity specific results of the trial's primary outcomes are reported regardless of whether there are significant differences by sex or race. Yes Diverse Representation -ParticipantsWere steps taken to ensure diverse representation among trial participants, and if so, are these efforts outlined in the methods?If No, a lack of diversity should be explained and listed as a limitation. Yes Diverse Representation -Steering CommitteeWere steps taken to ensure diverse representation among the trial steering committee, and if so, are these efforts outlined in the Methods including demographic information?If No, a lack of diversity should be explained and listed as a limitation.Yes

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.015
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.015
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0030.002
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.084
GPT teacher head0.387
Teacher spread0.302 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes2
Has abstractno

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