Expression and Localization of 5-HT Receptors in the Dorsal Horn of Rat and Human Spinal Cords
Bibliographic record
Abstract
Serotonin, or 5-HT, has gained attention in chronic pain research. While studies in rodents and serotonergic drugs link 5-HT to spinal pain processing, its mechanisms remain unclear. Human spinal cord studies on 5-HT receptor expression and potential sex differences are limited. This study maps 5-HT receptor distribution in rat and human spinal pain circuits using immunohistochemistry, qRT-PCR, and single-cell/nuclei RNA sequencing. We analyzed the spinal expression of all 5-HT receptor subtypes, focusing on 5-HT2C in dorsal horn circuits across spinal regions, sex, and species. Findings show dense expression of 5-HT2C and other subtypes in the dorsal horn's superficial laminae, crucial for nociception, in both rats and humans. This suggests spinal serotonin transmission plays a role in pain modulation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".